Clinical and functional outcomes at 7-year follow-up of children presenting putative antecedents of schizophrenia at age 9-12 years.

Autor: Cullen AE; Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK. alexis.cullen@kcl.ac.uk.; Division of Insurance Medicine, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden. alexis.cullen@kcl.ac.uk., Roberts RE; Education & Training Division, Anna Freud, London, UK.; Research Department of Clinical, Educational & Health Psychology, University College London, London, UK., Fisher HL; Institute of Psychiatry, Psychology & Neuroscience, Social, Genetic & Developmental Psychiatry Centre, King's College London, London, UK.; ESRC Centre for Society and Mental Health, King's College London, London, UK., Laurens KR; Institute of Psychiatry, Psychology & Neuroscience, Social, Genetic & Developmental Psychiatry Centre, King's College London, London, UK.; School of Psychology and Counselling, Queensland University of Technology (QUT), Brisbane, QLD, Australia.
Jazyk: angličtina
Zdroj: Schizophrenia (Heidelberg, Germany) [Schizophrenia (Heidelb)] 2024 Sep 30; Vol. 10 (1), pp. 83. Date of Electronic Publication: 2024 Sep 30.
DOI: 10.1038/s41537-024-00507-8
Abstrakt: Identification of youth presenting early risk factors for psychosis may facilitate preventive intervention. Through school-based screening, we recruited 112 children aged 9-12 years who presented multiple putative antecedents of schizophrenia (ASz), a family history of schizophrenia (FHx), or neither of these risk factors (typically-developing; TD). Clinical and functional outcomes were assessed at age 17-21 years (N = 93). Compared to the TD group, the ASz group had higher total Prodromal Questionnaire (PQ) scores (β = 10.59, 95% CI = 3.76, 17.42) and total psychopathology scores (β = 6.13, 95% CI: 1.03, 11.23), were more likely to score above-threshold on the PQ positive symptoms scale (OR = 4.00, 95% CI = 1.08, 14.83), and had lower scores on the Social and Occupational Functioning Scale (β = -9.43, 95% CI = -15.08, -3.77) at follow-up. The FHx and TD groups did not differ on any outcome. Findings suggest that population screening for putative antecedents of schizophrenia may identify children who would benefit from preventative intervention.
(© 2024. The Author(s).)
Databáze: MEDLINE
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