Metabolic syndrome is associated with reduced default mode network functional connectivity in young post-9/11 Veterans.

Autor: Knoff AA; Translational Research Center for TBI and Stress Disorders (TRACTS 182-JP), VA Boston Healthcare System, 150 S. Huntington Avenue, Boston, MA, 02130, USA. aubrey.knoff@va.gov.; Department of Psychiatry, Harvard Medical School, Boston, MA, USA. aubrey.knoff@va.gov.; Department of Psychiatry, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA. aubrey.knoff@va.gov., Nowak MK; Translational Research Center for TBI and Stress Disorders (TRACTS 182-JP), VA Boston Healthcare System, 150 S. Huntington Avenue, Boston, MA, 02130, USA.; Department of Psychiatry, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA.; National Center for PTSD at VA Boston Healthcare System, Boston, MA, USA., Van Etten EJ; Translational Research Center for TBI and Stress Disorders (TRACTS 182-JP), VA Boston Healthcare System, 150 S. Huntington Avenue, Boston, MA, 02130, USA.; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.; Department of Psychiatry, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA., Andreu-Arasa VC; Department of Radiology, VA Boston Healthcare System, Boston, MA, USA.; Department of Radiology, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA., Esterman M; Translational Research Center for TBI and Stress Disorders (TRACTS 182-JP), VA Boston Healthcare System, 150 S. Huntington Avenue, Boston, MA, 02130, USA.; Department of Psychiatry, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA.; National Center for PTSD at VA Boston Healthcare System, Boston, MA, USA.; Neuroimaging Research for Veterans Center, VA Boston Healthcare System, Boston, MA, USA., Leritz EC; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.; Geriatric Research, Educational and Clinical Center (GRECC), VA Boston Healthcare System, Boston, MA, USA., Fortenbaugh FC; Translational Research Center for TBI and Stress Disorders (TRACTS 182-JP), VA Boston Healthcare System, 150 S. Huntington Avenue, Boston, MA, 02130, USA.; Department of Psychiatry, Harvard Medical School, Boston, MA, USA., Milberg WP; Translational Research Center for TBI and Stress Disorders (TRACTS 182-JP), VA Boston Healthcare System, 150 S. Huntington Avenue, Boston, MA, 02130, USA.; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.; Geriatric Research, Educational and Clinical Center (GRECC), VA Boston Healthcare System, Boston, MA, USA., Fortier CB; Translational Research Center for TBI and Stress Disorders (TRACTS 182-JP), VA Boston Healthcare System, 150 S. Huntington Avenue, Boston, MA, 02130, USA.; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.; Geriatric Research, Educational and Clinical Center (GRECC), VA Boston Healthcare System, Boston, MA, USA., Salat DH; Translational Research Center for TBI and Stress Disorders (TRACTS 182-JP), VA Boston Healthcare System, 150 S. Huntington Avenue, Boston, MA, 02130, USA.; Geriatric Research, Educational and Clinical Center (GRECC), VA Boston Healthcare System, Boston, MA, USA.; Neuroimaging Research for Veterans Center, VA Boston Healthcare System, Boston, MA, USA.; Anthinoula A. Martinos Center for Biomedical Imaging, Boston, MA, USA.
Jazyk: angličtina
Zdroj: Brain imaging and behavior [Brain Imaging Behav] 2024 Sep 30. Date of Electronic Publication: 2024 Sep 30.
DOI: 10.1007/s11682-024-00927-1
Abstrakt: Metabolic syndrome is a collection of health factors that increases risk for cardiovascular disease. A condition of aging, metabolic syndrome is associated with reduced brain network integrity, including functional connectivity alterations among the default mode, regions vulnerable to neurodegeneration. Prevalence of metabolic syndrome is elevated in younger populations including post-9/11 Veterans and individuals with posttraumatic stress disorder, but it is unclear whether metabolic syndrome affects brain function in earlier adulthood. Identifying early effects of metabolic syndrome on brain network integrity is critical, as these impacts could contribute to increased risk for cognitive disorders later in life for Veterans. The current study examined whether metabolic syndrome and its individual components were associated with default mode functional connectivity. We also explored the contribution of posttraumatic stress disorder and traumatic brain injury on these metabolic syndrome-brain relationships. Post-9/11 Veterans with combat deployment history (95 with and 325 without metabolic syndrome) underwent functional magnetic resonance imaging to capture seed-based resting-state functional connectivity within the default mode. The metabolic syndrome group demonstrated reduced positive functional connectivity between the posterior cingulate cortex seed and the bilateral superior frontal gyrus. Data-driven analyses demonstrated that metabolic syndrome components, particularly cholesterol and central adiposity, were associated with widespread reductions in default mode network connectivity. Functional connectivity was also reduced in participants with metabolic syndrome but without current posttraumatic stress disorder diagnosis and with traumatic brain injury history. These results suggest that metabolic syndrome disrupts resting-state functional connectivity decades earlier than prior work has shown.
(© 2024. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.)
Databáze: MEDLINE
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