Study of the Association of Semen Parameters With Embryo Quality in a Tertiary Care Center in Bihar: A Retrospective Study.

Autor:	Kumari S; Reproductive Medicine, Indira Gandhi Institute of Medical Sciences (IGIMS), Patna, IND., Singh K; Reproductive Medicine, Indira Gandhi Institute of Medical Sciences (IGIMS), Patna, IND., Kumar A; General Medicine, Netaji Subhas Medical College and Hospital, Patna, IND., Kumari S; Reproductive Medicine, Indira Gandhi Institute of Medical Sciences (IGIMS), Patna, IND., Raina A; Reproductive Medicine, Indira Gandhi Institute of Medical Sciences (IGIMS), Patna, IND.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2024 Aug 30; Vol. 16 (8), pp. e68209. Date of Electronic Publication: 2024 Aug 30 (Print Publication: 2024).
DOI:	10.7759/cureus.68209
Abstrakt:	Introduction Semen quality, characterized by parameters such as sperm count, motility, and morphology, determines successful fertilization and subsequent embryo health. This study investigates the impact of sperm parameters on embryo quality in assisted reproductive technology (ART). Methods The study utilized a retrospective design with 194 male and 194 female participants who underwent fertility treatment from October 2020 to May 2024. Semen analysis included assessment of sperm count, motility, and morphology. Embryo quality was evaluated on days three and five post-fertilizations based on morphological criteria. Statistical analyses, including one-way ANOVA and chi-square tests, explored relationships between semen parameters and embryo quality. Results The study included 388 participants (males: 194 and females: 194). Female participants had a mean age of 31.0 ± 4.6 years and a mean BMI of 23.1 ± 5.3 kg/m², while males had a mean age of 36.6 ± 5.4 years and a mean BMI of 22.7 ± 2.8 kg/m². Paternal age and BMI showed no significant association (p > 0.05) with embryo quality. However, sperm quality parameters such as sperm count, motility, and morphology demonstrated significant associations (p < 0.05) with embryo quality on both day three and day five, indicating that abnormal sperm parameters were linked to poorer embryo quality. Factors such as alcohol consumption, smoking, tobacco use, living in industrial areas, and tea/coffee consumption showed no significant association with embryo quality. Conclusion The findings of the study emphasize the importance of comprehensive semen analysis in fertility assessments and highlight opportunities for improving ART outcomes through targeted interventions and further mechanistic research. Competing Interests: Human subjects: Consent was obtained or waived by all participants in this study. Institutional Ethics Committee of Indira Gandhi Institute of Medical Sciences issued approval 1321/IEC/IGIMS/2023. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. (Copyright © 2024, Kumari et al.)
Databáze:	MEDLINE
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