Bifidobacterium longum and microbiome maturation modify a nutrient intervention for stunting in Zimbabwean infants.

Autor:	Gough EK; Department of International Health, Johns Hopkins Bloomberg School of Public Health; Baltimore, MD, USA. Electronic address: egough1@jh.edu., Edens TJ; Devil's Staircase Consulting, West Vancouver, BC, Canada., Carr L; Department of Microbiology and Immunology, University of British Columbia; Vancouver, BC, Canada., Robertson RC; Blizard Institute, Queen Mary University of London, London, UK., Mutasa K; Zvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe., Ntozini R; Zvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe., Chasekwa B; Zvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe., Geum HM; School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada., Baharmand I; School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada., Gill SK; School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada., Mutasa B; Zvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe., Mbuya MNN; Zvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe; Global Alliance for Improved Nutrition, Washington, DC, 20036, USA., Majo FD; Zvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe., Tavengwa N; Zvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe., Francis F; Department of Experimental Medicine, University of British Columbia, Vancouver, BC, Canada., Tome J; Zvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe., Evans C; Blizard Institute, Queen Mary University of London, London, UK; Zvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe; Department of Clinical Infection, Microbiology and Immunology, University of Liverpool, Liverpool, UK., Kosek M; University of Virginia School of Medicine, Charlottesville, VA, USA., Prendergast AJ; Blizard Institute, Queen Mary University of London, London, UK; Zvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe., Manges AR; School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada; British Columbia Centre for Disease Control (BCCDC), Vancouver, BC, Canada.
Jazyk:	angličtina
Zdroj:	EBioMedicine [EBioMedicine] 2024 Oct; Vol. 108, pp. 105362. Date of Electronic Publication: 2024 Sep 27.
DOI:	10.1016/j.ebiom.2024.105362
Abstrakt:	Background: Small-quantity lipid-based nutrient supplements (SQ-LNS), which has been widely tested to reduce child stunting, has largely modest effects to date, but the mechanisms underlying these modest effects are unclear. Child stunting is a longstanding indicator of chronic undernutrition and it remains a prevalent public health problem. The infant gut microbiome may be a key contributor to stunting; and mother and infant fucosyltransferase (FUT) phenotypes are important determinants of infant microbiome composition. Methods: We investigated whether mother-infant FUT status (n = 792) and infant gut microbiome composition (n = 354 fecal specimens from 172 infants) modified the impact of an infant and young child feeding (IYCF) intervention, that included SQ-LNS, on stunting at age 18 months in secondary analysis of a randomized trial in rural Zimbabwe. Findings: We found that the impact of the IYCF intervention on stunting was modified by: (i) mother-infant FUT2+/FUT3- phenotype (difference-in-differences -32.6% [95% CI: -55.3%, -9.9%]); (ii) changes in species composition that reflected microbiome maturation (difference-in-differences -68.1% [95% CI: -99.0%, -28.5%); and (iii) greater relative abundance of B. longum (differences-in-differences 49.1% [95% CI: 26.6%, 73.6%]). The dominant strains of B. longum when the intervention started were most similar to the proficient milk oligosaccharide utilizer subspecies infantis, which decreased with infant age and differed by mother-infant FUT2+/FUT3- phenotypes. Interpretation: These findings indicate that a persistently "younger" microbiome at initiation of the intervention reduced its benefits on stunting in areas with a high prevalence of growth restriction. Funding: Bill and Melinda Gates Foundation, UK DFID/Aid, Wellcome Trust, Swiss Agency for Development and Cooperation, US National Institutes of Health, UNICEF, and Nutricia Research Foundation. Competing Interests: Declaration of interests AJP was supported by Wellcome Trust grant 108065/Z/15/Z. ARM was supported by Bill & Melinda Gates Foundation grant OPP1021542 and OPP1143707, with a subcontract to the University of British Columbia 20R25498 EKG was supported by The Nutricia Research Foundation grant 2021-52. T.J.E. was paid a scientific consulting fee in relation to the analysis of the data presented here by the Zvitambo Institute for Maternal and Child Health Research. RCR declares remittance from Abbott Nutrition Health Institute and Nutricia for public conference talks outside of the submitted work in the past 36 months. All other authors declare that they have no competing interests. (Copyright © 2024 The Author(s). Published by Elsevier B.V. All rights reserved.)
Databáze:	MEDLINE
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