| Autor: |
Intakhan N; School of Allied Health Sciences, Walailak University, Nakhon Si Thammarat 80160, Thailand.; Center of Excellence Research for Melioidosis and Microorganisms, School of Allied Health Sciences, Walailak University, Nakhon Si Thammarat 80160, Thailand., Saeung A; Department of Parasitology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand., Rodrigues Oliveira SM; CICECO-Aveiro Institute of Materials, University of Aveiro, 3810-193 Aveiro, Portugal.; HMRI-Hunter Medical Research Institute, New Lambton, NSW 2305, Australia., Pereira ML; CICECO-Aveiro Institute of Materials, University of Aveiro, 3810-193 Aveiro, Portugal.; Department of Medical Sciences, University of Aveiro, 3810-193 Aveiro, Portugal., Chanmol W; School of Allied Health Sciences, Walailak University, Nakhon Si Thammarat 80160, Thailand.; Center of Excellence Research for Melioidosis and Microorganisms, School of Allied Health Sciences, Walailak University, Nakhon Si Thammarat 80160, Thailand. |
| Abstrakt: |
Leishmaniasis is a tropical infectious disease caused by Leishmania parasites. The disease can be spread by the bite of an infected sand fly. Currently, five chemotherapeutic drugs are available in leishmaniasis treatment. However, these drugs exhibit toxicity and serious adverse effects on infected individuals, necessitating alternative treatment strategies. One such strategy involves using combinations of existing antileishmanial drugs. In this study, we evaluated the interaction between artesunate (AS) and three antileishmanial drugs-amphotericin B (AmB), miltefosine (MF), and paromomycin (PM) against Leishmania infantum . This evaluation marks the first time such an assessment has been conducted. The Chou-Talalay combination index method was employed to analyze the drug interaction. The findings revealed that the interaction between AS and AmB ranged from antagonistic to synergistic, while the interaction between AS and MF showed moderate to strong synergism. In contrast, the interaction between AS and PM resulted in an antagonistic interaction, which differs from the combinations with AmB or MF. This study provides valuable insights for developing novel drug regimens for leishmaniasis treatment, emphasizing the potential of AS and its combination with existing antileishmanial drugs. Further research is necessary to optimize drug combinations and minimize adverse effects, leading to more effective therapeutic outcomes. |
