Association between reduced left ventricular ejection fraction and functional outcomes in acute stroke: Systematic review and meta-analysis.

Autor: de Oliveira BFS; Faculty of Medicine of Bahia, Federal University of Bahia, Bahia, Brazil. Electronic address: bruno.oliveira@ufba.br., de Santana CVC; Faculty of Medicine of Bahia, Federal University of Bahia, Bahia, Brazil., Bispo RG; Faculty of Medicine of Bahia, Federal University of Bahia, Bahia, Brazil., Oliveira-Filho J; Faculty of Medicine of Bahia, Federal University of Bahia, Bahia, Brazil.
Jazyk: angličtina
Zdroj: Clinical neurology and neurosurgery [Clin Neurol Neurosurg] 2024 Nov; Vol. 246, pp. 108566. Date of Electronic Publication: 2024 Sep 21.
DOI: 10.1016/j.clineuro.2024.108566
Abstrakt: Introduction: Left ventricular ejection fraction (LVEF) is a measure of cardiac function and often reduced LVEF is indicative of cardiomyopathy/heart failure. The current study evaluated whether reduced LVEF is associated with poor outcomes and mortality in acute stroke.
Methods: Articles that compared poor outcomes (modified Rankin scale 3-6) or mortality in people with reduced LVEF compared to preserved LVEF in acute ischemic stroke were searched in the following databases: MEDLINE/PubMed, Embase, Scopus, Biomed central, and Cochrane Library. The last search was on March 17, 2024. The results obtained were pooled in meta-analyses.
Results: A total of 28933 participants were enrolled from 17 articles. Reduced left ventricular ejection fraction was independently associated with poor outcomes at 90 days (OR:2.38 CI95 % 1.52;3.71; I² = 71 %), the same was observed for death at 90 days (OR:3.15 CI 95 % 1.43; 6.96; I² = 60 %).
Conclusion: Reduced LVEF is associated with poor functional outcomes and death within 3 months after acute ischemic stroke compared to the setting in which LVEF is preserved.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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