New Tricyclic Aryl Quinazoline Derivatives by Suzuki-Miyaura Cross-Coupling.

Autor: Elmuradov B; Leibniz Universität Hannover, Institut für Organische Chemie, Schneiderberg 1B, D-30167, Hannover, Germany.; Institute of the Chemistry of Plant Substances, Academy of Sciences of Uzbekistan, 100170, Mirzo-Ulugbek str. 77, Tashkent, Uzbekistan., Okmanov R; Institute of the Chemistry of Plant Substances, Academy of Sciences of Uzbekistan, 100170, Mirzo-Ulugbek str. 77, Tashkent, Uzbekistan., Juraev B; Institute of the Chemistry of Plant Substances, Academy of Sciences of Uzbekistan, 100170, Mirzo-Ulugbek str. 77, Tashkent, Uzbekistan., Dräger G; Leibniz Universität Hannover, Institut für Organische Chemie, Schneiderberg 1B, D-30167, Hannover, Germany., Butenschön H; Leibniz Universität Hannover, Institut für Organische Chemie, Schneiderberg 1B, D-30167, Hannover, Germany.
Jazyk: angličtina
Zdroj: ChemistryOpen [ChemistryOpen] 2024 Sep 27, pp. e202400197. Date of Electronic Publication: 2024 Sep 27.
DOI: 10.1002/open.202400197
Abstrakt: A number of new deoxyvasicinone (2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one) and mackinazolinone (6,7,8,9-tetrahydro-11H-pyrido[2,1-b]quinazolin-11-one) derivatives with aryl substituents at C7/C8 and at C5 are reported. These compounds are rare representatives of their kind and were prepared in high yields by Suzuki-Miyaura cross-coupling reactions between 7-bromo-2,3-dihydro[2,1-b]quinazoline-9-(1H)-one, 5,7-dibromo-2,3-dihydro[2,1-b]quinazoline-9-(1H)-one or 8-bromomackinazolinone and respective arylboronic acids with palladium acetate as the catalyst. The products were characterized spectroscopically and, in addition, by X-ray crystal structure analyses in six cases.
(© 2024 The Authors. ChemistryOpen published by Wiley-VCH GmbH.)
Databáze: MEDLINE
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