Diurnal variation of serum phosphorus concentrations in intact male adult domestic cats.

Autor: Chiang CF; Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California, Davis, Davis, California, USA., Vanderstichel R; Department of Clinical Veterinary Sciences, College of Veterinary Medicine, Long Island University, Brooklyn, New York, USA., Stockman J; Department of Clinical Veterinary Sciences, College of Veterinary Medicine, Long Island University, Brooklyn, New York, USA., Larsen JA; Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, Davis, California, USA., Fascetti AJ; Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, Davis, California, USA.
Jazyk: angličtina
Zdroj: Journal of veterinary internal medicine [J Vet Intern Med] 2024 Nov-Dec; Vol. 38 (6), pp. 3153-3161. Date of Electronic Publication: 2024 Sep 26.
DOI: 10.1111/jvim.17202
Abstrakt: Background: Monitoring serum phosphorus concentrations is crucial in the management of chronic kidney disease in cats. The diurnal variation of serum phosphorus concentration may affect clinical assessment.
Hypothesis/objectives: Characterize the diurnal variation of serum phosphorus concentration in cats and determine the associations between changes in serum phosphorus concentration and several metabolites of phosphorus metabolism.
Animals: Six apparently healthy, intact male, specific-pathogen-free cats were housed in a photoperiod, humidity, and temperature-controlled facility.
Methods: Blood sampling was performed hourly for 24 hours to obtain the serum concentrations of phosphorus, ionized calcium, parathyroid hormone, and calcidiol. Results were analyzed using linear mixed-effect models to determine the significance of diurnal variation and associations between serum phosphorus concentrations and other metabolites over time.
Results: Diurnal variation in serum phosphorus concentration was noted with an apex around 11:00 followed by gradually declining concentrations to reach the nadir around 23:00. The serum phosphorus concentration again increased through the early morning on the next day. An approximately 25% difference in serum phosphorus concentration at the apex and the nadir was documented. A non-linear relationship between the serum concentrations of phosphorus and ionized calcium over time was identified.
Conclusions and Clinical Importance: Diurnal variations of serum phosphorus concentration and associations between the trending of serum phosphorus and ionized calcium concentrations were evident in a group of clinically healthy adult cats housed in a controlled environment. These findings can help in the interpretation of clinical and research data regarding calcium and phosphorus metabolism and kidney health in cats.
(© 2024 The Author(s). Journal of Veterinary Internal Medicine published by Wiley Periodicals LLC on behalf of the American College of Veterinary Internal Medicine.)
Databáze: MEDLINE
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