Software using artificial intelligence for nodule and cancer detection in CT lung cancer screening: systematic review of test accuracy studies.

Autor:	Geppert J; Warwick Screening & Warwick Evidence, Warwick Medical School, University of Warwick, Coventry, UK., Asgharzadeh A; Population Health Science, University of Bristol, Bristol, UK.; Warwick Evidence, Warwick Medical School, University of Warwick, Coventry, UK., Brown A; Warwick Evidence, Warwick Medical School, University of Warwick, Coventry, UK., Stinton C; Warwick Screening & Warwick Evidence, Warwick Medical School, University of Warwick, Coventry, UK., Helm EJ; Department of Radiology, University Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK., Jayakody S; Warwick Evidence, Warwick Medical School, University of Warwick, Coventry, UK., Todkill D; Warwick Evidence, Warwick Medical School, University of Warwick, Coventry, UK., Gallacher D; Warwick Evidence, Warwick Medical School, University of Warwick, Coventry, UK., Ghiasvand H; Warwick Evidence, Warwick Medical School, University of Warwick, Coventry, UK.; Research Centre for Healthcare and Communities, Coventry University, Coventry, UK., Patel M; Warwick Evidence, Warwick Medical School, University of Warwick, Coventry, UK., Auguste P; Warwick Evidence, Warwick Medical School, University of Warwick, Coventry, UK., Tsertsvadze A; Warwick Evidence, Warwick Medical School, University of Warwick, Coventry, UK., Chen YF; Warwick Evidence, Warwick Medical School, University of Warwick, Coventry, UK Y-F.Chen@warwick.ac.uk., Grove A; Warwick Evidence, Warwick Medical School, University of Warwick, Coventry, UK., Shinkins B; Warwick Screening & Warwick Evidence, Warwick Medical School, University of Warwick, Coventry, UK., Clarke A; Warwick Evidence, Warwick Medical School, University of Warwick, Coventry, UK., Taylor-Phillips S; Warwick Screening, Warwick Medical School, University of Warwick, Coventry, UK.
Jazyk:	angličtina
Zdroj:	Thorax [Thorax] 2024 Oct 16; Vol. 79 (11), pp. 1040-1049. Date of Electronic Publication: 2024 Oct 16.
DOI:	10.1136/thorax-2024-221662
Abstrakt:	Objectives: To examine the accuracy and impact of artificial intelligence (AI) software assistance in lung cancer screening using CT. Methods: A systematic review of CE-marked, AI-based software for automated detection and analysis of nodules in CT lung cancer screening was conducted. Multiple databases including Medline, Embase and Cochrane CENTRAL were searched from 2012 to March 2023. Primary research reporting test accuracy or impact on reading time or clinical management was included. QUADAS-2 and QUADAS-C were used to assess risk of bias. We undertook narrative synthesis. Results: Eleven studies evaluating six different AI-based software and reporting on 19 770 patients were eligible. All were at high risk of bias with multiple applicability concerns. Compared with unaided reading, AI-assisted reading was faster and generally improved sensitivity (+5% to +20% for detecting/categorising actionable nodules; +3% to +15% for detecting/categorising malignant nodules), with lower specificity (-7% to -3% for correctly detecting/categorising people without actionable nodules; -8% to -6% for correctly detecting/categorising people without malignant nodules). AI assistance tended to increase the proportion of nodules allocated to higher risk categories. Assuming 0.5% cancer prevalence, these results would translate into additional 150-750 cancers detected per million people attending screening but lead to an additional 59 700 to 79 600 people attending screening without cancer receiving unnecessary CT surveillance. Conclusions: AI assistance in lung cancer screening may improve sensitivity but increases the number of false-positive results and unnecessary surveillance. Future research needs to increase the specificity of AI-assisted reading and minimise risk of bias and applicability concerns through improved study design. Prospero Registration Number: CRD42021298449. Competing Interests: Competing interests: All authors have completed the ICMJE uniform disclosure. All authors involved in Warwick Evidence are wholly or partly funded by the NIHR. STP and AG are funded by the NIHR on personal fellowships. STP serves as Chair of the UK National Screening Committee Research and Methodology group, but this work is independent research not associated with that role. (© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY. Published by BMJ.)
Databáze:	MEDLINE
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