| Autor: |
Abel FM; National Institute of Standards and Technology (NIST), Gaithersburg, Maryland 20899, United States., Correa EL; National Institute of Standards and Technology (NIST), Gaithersburg, Maryland 20899, United States.; Theiss Research, La Jolla, California 92037, United States., Bui TQ; National Institute of Standards and Technology (NIST), Gaithersburg, Maryland 20899, United States., Biacchi AJ; National Institute of Standards and Technology (NIST), Gaithersburg, Maryland 20899, United States., Donahue MJ; National Institute of Standards and Technology (NIST), Gaithersburg, Maryland 20899, United States., Merritt MT; National Institute of Standards and Technology (NIST), Gaithersburg, Maryland 20899, United States.; Morgan State University, Baltimore, Maryland 21251, United States., Seppala JE; National Institute of Standards and Technology (NIST), Gaithersburg, Maryland 20899, United States., Woods SI; National Institute of Standards and Technology (NIST), Gaithersburg, Maryland 20899, United States., Hight Walker AR; National Institute of Standards and Technology (NIST), Gaithersburg, Maryland 20899, United States., Dennis CL; National Institute of Standards and Technology (NIST), Gaithersburg, Maryland 20899, United States. |
| Abstrakt: |
High-crystal-quality nanoferrites with short surface ligands (oleic acid) were recently shown to exhibit enhanced sensitivity and spatial resolution, likely due to chain formation (uniaxial assemblies of particles) for magnetic particle imaging (MPI). Here, we develop a simple one-pot thermal decomposition approach to produce ferrite (iron oxide) magnetic nano-objects (MNOs) that strongly interact magnetically and have good synthetic reproducibility. The ferrite MNOs were physically characterized by X-ray diffraction, Raman spectroscopy, transmission electron microscopy, and dynamic light scattering. The MNOs were magnetically characterized by magnetometry and magnetic particle spectroscopy (MPS) to study their interactions, dynamics, and suitability for spatially resolved magnetic thermometry. The MNOs were synthesized in a range of sizes between 12 nm and 27 nm, showing that MNOs below a minimum size do not exhibit dynamic interactions/significant increased response and that a larger field is required for chain formation as size increases. In addition to size effects, we explore the role of ligand length, environment (liquid vs solid), and concentration on the proposed chain formation. The experimental results were then correlated to micromagnetic simulations to gain further insight into the formation of chains. Compared to some existing MPI tracers, our ferrite MNOs exhibit enhanced signal (up to about 37×) and spatial resolution (up to about 9×) under certain limited (ferrite-MNO optimal) field and frequency conditions used. MPS as a function of temperature and drive field amplitude was performed, showing promise for spatially resolved thermometry. These results confirm the importance of tuning the frequency and amplitude of the drive field for optimal imaging/thermal performance. |
