Presence of kappa 2 light chain in normal rabbits and as induced auto anti-allotype antibody in kappa 1 light chain suppressed subjects.

Autor: Catty JP, Hole NJ, Catty D
Jazyk: angličtina
Zdroj: Molecular immunology [Mol Immunol] 1985 Aug; Vol. 22 (8), pp. 949-53.
DOI: 10.1016/0161-5890(85)90081-1
Abstrakt: Using an antiserum raised in b(bas)/b(bas)-suppressed rabbits to kappa 2 light chain we have shown that the kappa 2 light chain is an isotype of kappa 1, present in the majority of, if not all, rabbits. It probably exists in at least 2 allelic forms. It is capable of producing a functional antibody molecule (auto anti-b6) and compensates for the absence of kappa 1 light chain in homozygous b6-suppressed rabbits.
Databáze: MEDLINE