Health-Related Quality of Life After Neonatal Treatment of Symptomatic Tetralogy of Fallot: Insights from the Congenital Cardiac Research Collaborative.

Autor: Nicholson GT; Division of Cardiology, Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN, USA. george.t.nicholson@vumc.org.; Thomas P. Graham Jr. Division of Pediatric Cardiology, Pediatric Heart Institute, Vanderbilt University Medical Center, 2200 Children's Way, 5230 Doctors' Office Tower, Nashville, TN, 37232, USA. george.t.nicholson@vumc.org., Zampi JD; Division of Cardiology, Department of Pediatrics, C.S. Mott Children's Hospital, University of Michigan School of Medicine, Ann Arbor, MI, USA., Glatz AC; Division of Cardiology, Department of Pediatrics, Washington University School of Medicine, St. Louis, MA, USA., Goldstein BH; Department of Pediatrics, Heart Institute, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Petit CJ; Morgan Stanley Children's Hospital, Columbia University Vagelos College of Physicians & Surgeons, New York, NY, USA., Zhang Y; Morgan Stanley Children's Hospital, Columbia University Vagelos College of Physicians & Surgeons, New York, NY, USA., McCracken CE; Center for Research and Evaluation, Kaiser Permanente Georgia, Atlanta, GA, USA., Qureshi AM; Lillie Frank Abercrombie Division of Cardiology, Department of Pediatrics, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA., Goldberg CS; Division of Cardiology, Department of Pediatrics, C.S. Mott Children's Hospital, University of Michigan School of Medicine, Ann Arbor, MI, USA., Romano JC; Section of Pediatric Cardiothoracic Surgery, Department of Cardiac Surgery, C.S. Mott Children's Hospital, University of Michigan School of Medicine, Ann Arbor, MI, USA., Law MA; Division of Pediatric Cardiology, Department of Pediatrics, Children's of Alabama, University of Alabama Birmingham School of Medicine, Birmingham, AL, USA., Meadows JJ; Division of Cardiology, Department of Pediatrics, University of California San Francisco School of Medicine, San Francisco, CA, USA., Shahanavaz S; The Heart Institute, Cincinnati Children's Hospital Medical Center and Division of Pediatric Cardiology, University of Cincinnati College of Medicine, Cincinnati, OH, USA., Batlivala SP; The Heart Institute, Cincinnati Children's Hospital Medical Center and Division of Pediatric Cardiology, University of Cincinnati College of Medicine, Cincinnati, OH, USA., Maskatia SA; Division of Pediatric Cardiology, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA., Beshish A; Children's Heart Center Cardiology, Department of Pediatrics, Children's Healthcare of Atlanta, Emory University School of Medicine, Atlanta, GA, USA., O'Byrne ML; The Cardiac Center at the Children's Hospital of Philadelphia, Philadelphia, PA, USA., Ligon RA; Children's Heart Center Cardiology, Department of Pediatrics, Children's Healthcare of Atlanta, Emory University School of Medicine, Atlanta, GA, USA., Stack KO; The Cardiac Center at the Children's Hospital of Philadelphia, Philadelphia, PA, USA., Khan HQ; Lillie Frank Abercrombie Division of Cardiology, Department of Pediatrics, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA., Parekh S; Division of Cardiology, Department of Pediatrics, University of California San Francisco School of Medicine, San Francisco, CA, USA.; Connecticut Children's Hospital, Hartford, CT, USA., Ilardi DL; Pediatric Neurodevelopmental Center, Atlanta, GA, USA.
Jazyk: angličtina
Zdroj: Pediatric cardiology [Pediatr Cardiol] 2024 Sep 21. Date of Electronic Publication: 2024 Sep 21.
DOI: 10.1007/s00246-024-03650-2
Abstrakt: To evaluate the association between initial management strategy of neonatal symptomatic Tetralogy of Fallot (sTOF) and later health-related quality of life (HRQOL) outcomes. We performed a multicenter, cross-sectional evaluation of a previously assembled cohort of infants with sTOF who underwent initial intervention at ≤ 30 days of age, between 2005 and 2017. Eligible patients' parents/guardians completed an age-appropriate Pediatric Quality of Life Inventory, a Pediatric Quality of Life Inventory Cardiac Module Heart Disease Symptoms Scale, and a parental survey. The association between treatment strategy and HRQOL was evaluated, and the entire sTOF cohort was compared to published values for the healthy pediatric population and to children with complex congenital heart disease and other chronic illness. The study cohort included 143 sTOF subjects, of which 59 underwent a primary repair, and 84 had a staged repair approach. There was no association between initial management strategy and lower HRQOL. For the entire cohort, in general, individual domain scores decreased as age sequentially increased. Across domain measurements, mean scores for the sTOF cohort were significantly lower than the healthy pediatric population and comparable to those with other forms of complex CHD and other chronic health conditions. The presence of a genetic syndrome was significantly associated with a poor HRQOL (p = 0.003). Initial treatment strategy for sTOF was not associated with differences in late HRQOL outcomes, though the overall HRQOL in this sTOF cohort was significantly lower than the general population, and comparable to others with chronic illness.
(© 2024. The Author(s).)
Databáze: MEDLINE
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