Intercalation of multilayered Ti 3 C 2 T x  electrode doped with vanadium for highly sensitive electrochemical detection of dopamine in biological samples.

Autor: Ramadoss J; Centre for High-Pressure Research, School of Physics, Bharathidasan University, Tiruchirappalli, 620024, Tamil Nadu, India.; International Ph.D. Program in Innovative Technology of Biomedical Engineering and Medical Devices, Ming Chi University of Technology, New Taipei City, 24301, Taiwan., Sonachalam A; Centre for High-Pressure Research, School of Physics, Bharathidasan University, Tiruchirappalli, 620024, Tamil Nadu, India. sarumugam1963@yahoo.com.; Tamil Nadu Open University, Chennai, 600015, India. sarumugam1963@yahoo.com., Yusuf K; Department of Chemistry, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia., Govindasamy M; International Ph.D. Program in Innovative Technology of Biomedical Engineering and Medical Devices, Ming Chi University of Technology, New Taipei City, 24301, Taiwan. govindasamy420700@gmail.com.; Research Center for Intelligence Medical Devices, Ming Chi University of Technology, New Taipei City, 243303, Taiwan. govindasamy420700@gmail.com.; Centre for Applied Research, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences (SIMATS), Chennai, 602105, Tamil Nadu, India. govindasamy420700@gmail.com.
Jazyk: angličtina
Zdroj: Mikrochimica acta [Mikrochim Acta] 2024 Sep 21; Vol. 191 (10), pp. 613. Date of Electronic Publication: 2024 Sep 21.
DOI: 10.1007/s00604-024-06653-1
Abstrakt: The electrochemical detection characteristics of the layered Ti 3 C 2 T x material were enhanced by modifying its surface. Ti 3 C 2 T x is used as the Ti - F chemical bond weakens with increasing pH levels. Ti 3 C 2 T x is alkalinized by KOH, and F is substituted for - OH. The surface hydroxyl groups can be eliminated by intercalating K + . This study elaborates on the hydrothermal production of vanadium-doped layered Ti 3 C 2 T x nanosheets intercalated with K + . The development of a sensitive dopamine electrochemical sensor is outlined by intercalating a vanadium-doped multilayered K + Ti 3 C 2 T x electrode. The chemical, surface, and structural composition of the synthesized electrode for dopamine detection was investigated and confirmed. The sensor exhibits a linear range (1-10 µM), a low detection limit (8.4 nM), and a high sensitivity of 2.746 µAµM -1 cm -2 under optimal electrochemical testing conditions. The sensor also demonstrates exceptional anti-interference capabilities and stability. The sensor was applied to detection of dopamine in (spiked) rat brains, human serum, and urine samples. This study introduces a novel approach by utilizing K + intercalation of vanadium-doped Ti 3 C 2 T x -based electrochemical sensors and an innovative method for dopamine detection. The dopamine detection revealed the potential of (V0.05) K + Ti 3 C 2 T x -GCE for practical application in pharmaceutical sample analysis.
(© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature.)
Databáze: MEDLINE
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