Detection of cefiderocol and aztreonam/avibactam resistance in epidemic Escherichia coli ST-361 carrying bla NDM-5 and bla KPC-3 from foreign fighters evacuated from Ukraine.

Autor: Martin MJ; Multidrug-Resistant Organism Repository and Surveillance Network (MRSN), Walter Reed Army Institute of Research, Silver Spring, Maryland, USA., Luo TL; Multidrug-Resistant Organism Repository and Surveillance Network (MRSN), Walter Reed Army Institute of Research, Silver Spring, Maryland, USA., Kovalchuk V; Department of Microbiology, National Pirogov Memorial Medical University, Vinnytsia, Ukraine., Kondratiuk V; Department of Emergency and Military Medicine, National Pirogov Memorial Medical University, Vinnytsia, Ukraine., Dao HD; Multidrug-Resistant Organism Repository and Surveillance Network (MRSN), Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.; Department of Pathology, Landstuhl Regional Medical Center, Landstuhl, Germany., Kovalenko I; Department of Microbiology, National Pirogov Memorial Medical University, Vinnytsia, Ukraine., Plaza BJ; Department of Pathology, Landstuhl Regional Medical Center, Landstuhl, Germany., Kettlewell JM; Department of Pathology, Landstuhl Regional Medical Center, Landstuhl, Germany., Anderson CP; Department of Pathology, Landstuhl Regional Medical Center, Landstuhl, Germany., Smedberg JR; Department of Pathology, Landstuhl Regional Medical Center, Landstuhl, Germany., Ong AC; Multidrug-Resistant Organism Repository and Surveillance Network (MRSN), Walter Reed Army Institute of Research, Silver Spring, Maryland, USA., Kwak YI; Multidrug-Resistant Organism Repository and Surveillance Network (MRSN), Walter Reed Army Institute of Research, Silver Spring, Maryland, USA., Hawley-Molloy JS; Division of Medicine, Landstuhl Regional Medical Center, Landstuhl, Germany., Bennett JW; Multidrug-Resistant Organism Repository and Surveillance Network (MRSN), Walter Reed Army Institute of Research, Silver Spring, Maryland, USA., McGann PT; Multidrug-Resistant Organism Repository and Surveillance Network (MRSN), Walter Reed Army Institute of Research, Silver Spring, Maryland, USA., Lebreton F; Multidrug-Resistant Organism Repository and Surveillance Network (MRSN), Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.
Jazyk: angličtina
Zdroj: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2024 Nov 06; Vol. 68 (11), pp. e0109024. Date of Electronic Publication: 2024 Sep 20.
DOI: 10.1128/aac.01090-24
Abstrakt: Genomic surveillance detected clonal Escherichia coli sequence type-361 isolates carrying bla NDM-5 , bla KPC-3 , bla CTX-M-15 , and rmtB1 from a patient in Ukraine and four wounded foreign soldiers evacuated to Germany. Isolates were non-susceptible to carbapenems, aminoglycosides, and cefiderocol and aztreonam/avibactam due to a PBP3 YRIN insertion and the bla CMY-145 AmpC β-lactamase. Coordinated surveillance efforts across civilian, military, and veteran healthcare systems are essential to prevent further spread as international volunteers return home after medical evacuation from Ukraine.
Competing Interests: The authors declare no conflict of interest.
Databáze: MEDLINE
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