No impact of HIV coinfection on the mortality in patients with hepatitis C virus infection after sustained virological response.

Autor:	Martín-Carmona J; Cinical Virology and STIs Group, Unit of Infectious Diseases and Microbiology, Hospital Universitario de Valme, Seville, Spain.; Instituto de Biomedicina de Sevilla (IBiS)/CSIC, Seville, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, Madrid, Spain.; Universidad de Sevilla (US), Sevilla, Spain., Corma-Gómez A; Cinical Virology and STIs Group, Unit of Infectious Diseases and Microbiology, Hospital Universitario de Valme, Seville, Spain.; Instituto de Biomedicina de Sevilla (IBiS)/CSIC, Seville, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, Madrid, Spain., Téllez F; Unit of Infectious Diseases, Hospital Universitario de Puerto Real, Faculty of Medicine, Universidad de Cádiz, Spain., Arenga-Barrios D; Infectious Diseases, Hospital Universitario de Puerto Real, Cádiz, Spain., Serrano-Fuentes M; Unit of Infectious Diseases, Hospital Universitario de Gran Canaria Dr Negrín, Las Palmas de Gran Canaria, Spain., Morano L; Unit of Infectious Diseases, Hospital Universitario Alvaro Cunqueiro, Vigo, Spain. Instituto de Investigación Sanitaria Galicia Sur (IISGS), Spain., Corona-Mata D; Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, Madrid, Spain.; Clinical Virology and Zoonoses Research Group, Unit of Infectious Diseases, Hospital Universitario Reina Sofía, Spain.; Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Spain.; Universidad de Córdoba (UCO), Córdoba, Spain., Navarrete Lorite MN; Unit of Infectious Diseases, Hospital Universitario Virgen Macarena, Sevilla, Spain., Vera-Méndez FJ; Section of Infectious Medicine/Service of Internal Medicine, Hospital General Universitario Santa Lucía, Cartagena, Spain., Alados JC; Unit of Clinical Microbiology, University Hospital Jerez, Cadiz, Spain., Palacios R; Unit of Infectious Diseases and Microbiology, Hospital Virgen de la Victoria, Málaga, Spain., de Los Santos I; Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, Madrid, Spain.; Unit of Internal Medicine and Infectious Diseases, Hospital La Princesa, Madrid, Spain., Geijo P; Unit of Internal Medicine, Hospital General Virgen de la Luz, Cuenca, Spain., Imaz A; Unit of Infectious Diseases, Hospital Universitario Bellvitge, Barcelona, Spain., Merino D; Unit of Infectious Diseases and Microbiology, Hospital Universitario Juan Ramón Jimenez, Huelva, Spain., Reus-Bañuls SJ; Hospital General Universitario de Alicante, Alicante, Spain., Galindo MJ; Internal Medicine, Hospital Clínico Universitario de Valencia, Valencia, Spain., López-Ruz MÁ; Infectious Disease Unit, Internal Medicine Service, Virgen de las Nieves University Hospital, Granada, Spain., Galera C; Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain., Pineda JA; Cinical Virology and STIs Group, Unit of Infectious Diseases and Microbiology, Hospital Universitario de Valme, Seville, Spain.; Universidad de Sevilla (US), Sevilla, Spain., Macías J; Cinical Virology and STIs Group, Unit of Infectious Diseases and Microbiology, Hospital Universitario de Valme, Seville, Spain.; Instituto de Biomedicina de Sevilla (IBiS)/CSIC, Seville, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, Madrid, Spain.; Universidad de Sevilla (US), Sevilla, Spain.
Jazyk:	angličtina
Zdroj:	Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [Clin Infect Dis] 2024 Sep 18. Date of Electronic Publication: 2024 Sep 18.
DOI:	10.1093/cid/ciae473
Abstrakt:	Background: In patients with hepatitis C virus (HCV) chronic infection and advanced liver disease, the impact of human immunodeficiency virus (HIV) coinfection on the clinical outcome after sustained virological response (SVR) has not been sufficiently clarified. The aim of this study was to compare the mortality after SVR of patients bearing HCV chronic infection and advanced liver fibrosis, with and without HIV-coinfection after a prolonged follow-up. Methods: This was a prospective multicenter cohort study including individuals with HIV/HCV-coinfection and patients with HCV-monoinfection from Spain, fulfilling: 1) Liver stiffness (LS) ≥9.5 kPa before treatment; 2) SVR with a direct-acting antiviral (DAA) based regimen; 3) LS measurement available at SVR. The main outcome was overall survival. Mortality attributable to liver disease and non-hepatic causes was also assessed. Results: 1,118 patients were included, of whom 676 (60.5%) were living with HIV. The median (Q1-Q3) follow-up was 76 months (57-83). After SVR, 46 (10%) HCV-monoinfected and 74 (11%) HIV/HCV-coinfected patients died. The overall mortality rate (95% CI) was 1.9 (1.6-2.2) per 100 person-years, 1.9 (1.4-2.5) per 100 person-years in patients with HCV-monoinfection and 1.8 (1.6-2.3) per 100 person-years in people living with HIV. In the multivariable analysis, HIV-coinfection was not associated with a shorter survival [0.98 HR (95% confidence interval, CI) = (0.61-1.58), p=0.939]. Conclusions: In patients with HCV chronic infection and advanced fibrosis, HIV-coinfection does not reduce the overall survival after SVR. (© The Author(s) 2024. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.)
Databáze:	MEDLINE
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