Atypical Hemolytic Uremic Syndrome Following Influenza B: A Case Report.
| Autor: | McGraw KE; Mercer University School of Medicine, Savannah, GA., Porter AP; Mercer University School of Medicine, Savannah, GA., Moffitt AM; Mercer University School of Medicine, Savannah, GA., Golden MEM; Memorial Health University Medical Center, Savannah, GA.; Dwaine & Cynthia Willett Children's Hospital of Savannah., Stewart H; Memorial Health University Medical Center, Savannah, GA.; Dwaine & Cynthia Willett Children's Hospital of Savannah. |
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| Jazyk: | angličtina |
| Zdroj: | HCA healthcare journal of medicine [HCA Healthc J Med] 2024 Aug 01; Vol. 5 (4), pp. 459-464. Date of Electronic Publication: 2024 Aug 01 (Print Publication: 2024). |
| DOI: | 10.36518/2689-0216.1669 |
| Abstrakt: | Background: Atypical hemolytic uremic syndrome (aHUS) is a thrombotic microangiopathy that presents with a triad of hemolytic anemia, thrombocytopenia, and acute kidney impairment. It can be attributed to mutations in an array of different complement proteins leading to the overactivation of the complement system, the most impacted being the alternative pathway. Though rare, influenza B has been documented as a potential trigger to the development of aHUS. Case Presentation: We discuss a 10-year-old girl with a history of aHUS who was found to have a repeat episode of aHUS following an influenza B infection. There have only been a few reports of aHUS triggered by influenza B, making this a unique case. Given the recurrence and atypical features present in this case, a genetic workup was obtained, which showed a heterozygous mutation of complement protein CD46. The presence of mutations in CD46 is a known predisposing factor to aHUS, but influenza B infection is rarely implicated as a trigger to aHUS. The prognosis of aHUS varies and is dependent on the complement mutation specific to the individual. Conclusion: Patients with CD46 mutations have been shown to have high rates of relapse but less long-term kidney damage, as seen in this case. Clinicians should be aware of the association between influenza B and aHUS to improve patient outcomes. Competing Interests: Conflicts of Interest: The authors declare they have no conflicts of interest. (© 2024 HCA Physician Services, Inc. d/b/a Emerald Medical Education.) |
| Databáze: | MEDLINE |
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