Vagus nerve stimulation recruits the central cholinergic system to enhance perceptual learning.

Autor: Martin KA; Skirball Institute for Biomolecular Medicine, New York University School of Medicine, New York, NY, USA.; Neuroscience Institute, New York University School of Medicine, New York, NY, USA.; Department of Otolaryngology, New York University School of Medicine, New York, NY, USA.; Department of Neuroscience and Physiology, New York University School of Medicine, New York, NY, USA.; Center for Neural Science, New York University, New York, NY, USA., Papadoyannis ES; Skirball Institute for Biomolecular Medicine, New York University School of Medicine, New York, NY, USA.; Neuroscience Institute, New York University School of Medicine, New York, NY, USA.; Department of Otolaryngology, New York University School of Medicine, New York, NY, USA.; Department of Neuroscience and Physiology, New York University School of Medicine, New York, NY, USA., Schiavo JK; Skirball Institute for Biomolecular Medicine, New York University School of Medicine, New York, NY, USA.; Neuroscience Institute, New York University School of Medicine, New York, NY, USA.; Department of Otolaryngology, New York University School of Medicine, New York, NY, USA.; Department of Neuroscience and Physiology, New York University School of Medicine, New York, NY, USA., Fadaei SS; Skirball Institute for Biomolecular Medicine, New York University School of Medicine, New York, NY, USA.; Neuroscience Institute, New York University School of Medicine, New York, NY, USA.; Department of Otolaryngology, New York University School of Medicine, New York, NY, USA.; Department of Neuroscience and Physiology, New York University School of Medicine, New York, NY, USA., Issa HA; Skirball Institute for Biomolecular Medicine, New York University School of Medicine, New York, NY, USA.; Neuroscience Institute, New York University School of Medicine, New York, NY, USA.; Department of Otolaryngology, New York University School of Medicine, New York, NY, USA.; Department of Neuroscience and Physiology, New York University School of Medicine, New York, NY, USA., Song SC; Skirball Institute for Biomolecular Medicine, New York University School of Medicine, New York, NY, USA.; Neuroscience Institute, New York University School of Medicine, New York, NY, USA.; Department of Otolaryngology, New York University School of Medicine, New York, NY, USA.; Department of Neuroscience and Physiology, New York University School of Medicine, New York, NY, USA., Valencia SO; Skirball Institute for Biomolecular Medicine, New York University School of Medicine, New York, NY, USA.; Neuroscience Institute, New York University School of Medicine, New York, NY, USA.; Department of Otolaryngology, New York University School of Medicine, New York, NY, USA.; Department of Neuroscience and Physiology, New York University School of Medicine, New York, NY, USA., Temiz NZ; Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland., McGinley MJ; Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX, USA.; Department of Neuroscience, Baylor College of Medicine, Houston, TX, USA., McCormick DA; Institute of Neuroscience, University of Oregon, Eugene, OR, USA., Froemke RC; Skirball Institute for Biomolecular Medicine, New York University School of Medicine, New York, NY, USA. robert.froemke@med.nyu.edu.; Neuroscience Institute, New York University School of Medicine, New York, NY, USA. robert.froemke@med.nyu.edu.; Department of Otolaryngology, New York University School of Medicine, New York, NY, USA. robert.froemke@med.nyu.edu.; Department of Neuroscience and Physiology, New York University School of Medicine, New York, NY, USA. robert.froemke@med.nyu.edu.; Center for Neural Science, New York University, New York, NY, USA. robert.froemke@med.nyu.edu.
Jazyk: angličtina
Zdroj: Nature neuroscience [Nat Neurosci] 2024 Nov; Vol. 27 (11), pp. 2152-2166. Date of Electronic Publication: 2024 Sep 16.
DOI: 10.1038/s41593-024-01767-4
Abstrakt: Perception can be refined by experience, up to certain limits. It is unclear whether perceptual limits are absolute or could be partially overcome via enhanced neuromodulation and/or plasticity. Recent studies suggest that peripheral nerve stimulation, specifically vagus nerve stimulation (VNS), can alter neural activity and augment experience-dependent plasticity, although little is known about central mechanisms recruited by VNS. Here we developed an auditory discrimination task for mice implanted with a VNS electrode. VNS applied during behavior gradually improved discrimination abilities beyond the level achieved by training alone. Two-photon imaging revealed VNS induced changes to auditory cortical responses and activated cortically projecting cholinergic axons. Anatomical and optogenetic experiments indicated that VNS can enhance task performance through activation of the central cholinergic system. These results highlight the importance of cholinergic modulation for the efficacy of VNS and may contribute to further refinement of VNS methodology for clinical conditions.
(© 2024. The Author(s), under exclusive licence to Springer Nature America, Inc.)
Databáze: MEDLINE
Externí odkaz: