Preterm birth as a determinant of neurodevelopment and cognition in children (PRENCOG): protocol for an exposure-based cohort study in the UK.

Autor:	Boardman JP; Centre for Reproductive Health, University of Edinburgh, Edinburgh, UK James.Boardman@ed.ac.uk.; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK., Andrew R; Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK., Bastin ME; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK., Battersby C; Section of Neonatal Medicine, Imperial College London, London, UK., Batty GD; Department of Epidemiology and Public Health, University College London, London, UK., Cábez MB; Centre for Reproductive Health, University of Edinburgh, Edinburgh, UK.; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK., Cox SR; Lothian Birth Cohorts, Department of Psychology, The University of Edinburgh, Edinburgh, UK., Hall J; Centre for Reproductive Health, University of Edinburgh, Edinburgh, UK., Ingledow L; Adult Preemie Advocacy Network, London, UK., Marioni RE; Centre for Genomic and Experimental Medicine, University of Edinburgh, Edinburgh, UK., Modi N; Section of Neonatal Medicine, Imperial College London, London, UK., Murphy L; Edinburgh Clinical Research Facility, University of Edinburgh, Edinburgh, UK., Quigley AJ; Department of Radiology, NHS Lothian, Edinburgh, UK., Reynolds RM; Centre for Reproductive Health, University of Edinburgh, Edinburgh, UK.; Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK., Richardson H; School of Philosophy, Psychology, and Language Sciences, University of Edinburgh, Edinburgh, UK., Stock SJ; Usher Institute, Edinburgh Medical School, University of Edinburgh, Edinburgh, UK., Thrippleton MJ; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK., Tsanas A; Usher Institute, Edinburgh Medical School, University of Edinburgh, Edinburgh, UK.; The Alan Turing Institute, London, UK., Whalley HC; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
Jazyk:	angličtina
Zdroj:	BMJ open [BMJ Open] 2024 Sep 16; Vol. 14 (9), pp. e085365. Date of Electronic Publication: 2024 Sep 16.
DOI:	10.1136/bmjopen-2024-085365
Abstrakt:	Introduction: Preterm birth (PTB) is strongly associated with encephalopathy of prematurity (EoP) and neurocognitive impairment. The biological axes linking PTB with atypical brain development are uncertain. We aim to elucidate the roles of neuroendocrine stress activation and immune dysregulation in linking PTB with EoP. Methods and Analysis: PRENCOG (PREterm birth as a determinant of Neurodevelopment and COGnition in children: mechanisms and causal evidence) is an exposure-based cohort study at the University of Edinburgh. Three hundred mother-infant dyads comprising 200 preterm births (gestational age, GA <32 weeks, exposed) and 100 term births (GA >37 weeks, non-exposed), will be recruited between January 2023 and December 2027. We will collect parental and infant medical, demographic, socioeconomic characteristics and biological data which include placental tissue, umbilical cord blood, maternal and infant hair, infant saliva, infant dried blood spots, faecal material, and structural and diffusion MRI. Infant biosamples will be collected between birth and 44 weeks GA.EoP will be characterised by MRI using morphometric similarity networks (MSNs), hierarchical complexity (HC) and magnetisation transfer saturation imaging (MTsat). We will conduct: first, multivariable regressions and statistical association assessments to test how PTB-associated risk factors (PTB-RFs) relate to MSNs, HC and or MTsat; second, structural equation modelling to investigate neuroendocrine stress activation and immune dysregulation as mediators of PTB-RFs on features of EoP. PTB-RF selection will be informed by the variables that predict real-world educational outcomes, ascertained by linking the UK National Neonatal Research Database with the National Pupil Database. Ethics and Dissemination: A favourable ethical opinion has been given by the South East Scotland Research Ethics Committee 02 (23/SS/0067) and NHS Lothian Research and Development (2023/0150). Results will be reported to the Medical Research Council, in scientific media, via stakeholder partners and on a website in accessible language (https://www.ed.ac.uk/centre-reproductive-health/prencog). Competing Interests: Competing interests: REM is a scientific advisor to Optima Partners and the Epigenetic Clock Development Foundation. NM is the chief investigator for the National Neonatal Research Database. LM has received speaker and consultancy fees from Illumina. (© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY. Published by BMJ.)
Databáze:	MEDLINE
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