Animal models as windows into the pathogenesis of myopia: Illuminating new directions for vision health.

Autor: Chi J; Department of Ophthalmology, The Second Hospital of Jilin University, Changchun, 130042, PR China., Jiao Q; Department of Ophthalmology, The Second Hospital of Jilin University, Changchun, 130042, PR China., Li YZ; Department of Ophthalmology, The Second Hospital of Jilin University, Changchun, 130042, PR China., Zhang ZY; Department of Ophthalmology, The Second Hospital of Jilin University, Changchun, 130042, PR China., Li GY; Department of Ophthalmology, The Second Hospital of Jilin University, Changchun, 130042, PR China. Electronic address: l_gy@jlu.edu.cn.
Jazyk: angličtina
Zdroj: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2024 Nov 12; Vol. 733, pp. 150614. Date of Electronic Publication: 2024 Sep 05.
DOI: 10.1016/j.bbrc.2024.150614
Abstrakt: The incidence of myopia, particularly high myopia, is increasing annually. Myopia has gradually become one of the leading causes of global blindness and is a considerable public-health concern. However, the pathogenesis of myopia remains unclear, and exploring the mechanism underlying myopia has become an urgent scientific priority. Creating animal models of myopia is important for studying the pathogenesis of refractive errors. This approach allows researchers to study and analyze the pathogenesis of myopia from aspects such as changes in refractive development, pathological changes in eye tissue, and molecular pathways related to myopia. This review summarizes the examples of animal models, methods of inducing myopia experimentally, and molecular signaling pathways involved in developing myopia-induced animal models. This review provides solid literature for researchers in the field of myopia prevention and control. It offers guidance in selecting appropriate animal models and research methods to fit their research objectives. By providing new insights and a theoretical basis for studying mechanisms of myopia, we detail how elucidated molecular pathways can be exploited to translate into safe and effective measures for myopia prevention and control.
Competing Interests: Declaration of competing interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(Copyright © 2024 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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