| Autor: |
Shakirova OG; Nikolaev Institute of Inorganic Chemistry, Siberian Branch, Russian Academy of Sciences, Novosibirsk 630090, Russia.; Department of Chemistry and Chemical Technologies, Faculty of Machinery and Chemical Technologies, Federal State Budget Institution of Higher Education Komsomolsk-na-Amure State University, Komsomolsk-on-Amur 681013, Russia., Morozova TD; Department of Chemistry and Chemical Technologies, Faculty of Machinery and Chemical Technologies, Federal State Budget Institution of Higher Education Komsomolsk-na-Amure State University, Komsomolsk-on-Amur 681013, Russia., Kudyakova YS; Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, Yekaterinburg 620137, Russia., Bazhin DN; Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, Yekaterinburg 620137, Russia.; Department of Organic and Biomolecular Chemistry, Institute of Chemical Technology, Ural Federal University Named after the First President of Russia B.N. Yeltsin, Mira Str. 19, Yekaterinburg 620002, Russia., Kuratieva NV; Nikolaev Institute of Inorganic Chemistry, Siberian Branch, Russian Academy of Sciences, Novosibirsk 630090, Russia., Klyushova LS; Research Institute of Molecular Biology and Biophysics, FRC FTM, 2/12, Timakova Str., Novosibirsk 630060, Russia., Lavrov AN; Nikolaev Institute of Inorganic Chemistry, Siberian Branch, Russian Academy of Sciences, Novosibirsk 630090, Russia., Lavrenova LG; Nikolaev Institute of Inorganic Chemistry, Siberian Branch, Russian Academy of Sciences, Novosibirsk 630090, Russia. |
| Abstrakt: |
A new complex of copper(II) with methyl-5-(trifluoromethyl)pyrazol-3-yl-ketazine (H 2 L) was synthesized with the composition [Cu 2 L 2 ]∙C 2 H 5 OH ( 1 ). Recrystallization of the sample from DMSO yielded a single crystal of the composition [Cu 2 L 2 ((CH 3 ) 2 SO)] ( 2 ). The coordination compounds were studied by single-crystal X-ray diffraction analysis, IR spectroscopy, and static magnetic susceptibility method. The data obtained indicate that the polydentate ligand is coordinated by both acyclic nitrogen and heterocyclic nitrogen atoms. The cytotoxic activity of the ligand and complex 1 was investigated on human cell lines MCF7 (breast adenocarcinoma), Hep2 (laryngeal carcinoma), A549 (lung carcinoma), HepG2 (hepatocellular carcinoma), and MRC5 (non-tumor lung fibroblasts). The complex was shown to have a pronounced dose-dependent cytotoxicity towards these cell lines with LC 50 values in the range of 0.18-4.03 μM. |
