Surveillance of pathogenic yeasts in hospital environments in Taiwan in 2020.

Autor:	Tsai DJ; Taiwan Mycology Reference Center, National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Miaoli County, Taiwan., Hsieh LY; Taiwan Mycology Reference Center, National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Miaoli County, Taiwan., Chung PJ; Taiwan Mycology Reference Center, National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Miaoli County, Taiwan., Chen YZ; Taiwan Mycology Reference Center, National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Miaoli County, Taiwan., Jhou YJ; Taiwan Mycology Reference Center, National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Miaoli County, Taiwan., Tseng KY; Taiwan Mycology Reference Center, National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Miaoli County, Taiwan., Yang CJ; Department of Internal Medicine, Far Eastern Memorial Hospital, New Taipei, Taiwan., Yeh YC; Division of Infectious Disease, Department of Medicine, Kaohsiung Armed Forces General Hospital, Kaohsiung, Taiwan., Lin SY; Division of Infectious Diseases, Department of Internal Medicine, Camillians Saint Mary's Hospital Luodong, Yilan County, Taiwan., Shin-Jung Lee S; Division of Infectious Diseases, Department of Internal Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan., Wu TI; Department of Internal Medicine, Cathay General Hospital, Taipei, Taiwan., Chiang TT; Division of Infection, Department of Internal Medicine, Tri-Service General Hospital, Taipei, Taiwan., Chou CH; Department of Internal Medicine, Sin Lau Hospital, The Presbyterian Church of Taiwan, Tainan, Taiwan., Miu WC; Section of Infectious Diseases, Mennonite Christian Hospital, Hualien, Taiwan., Liu PY; Division of Infection, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan., Lu CT; Department of Infectious Diseases, Lo-Hsu Medical Foundation, Lotung Poh-Ai Hospital, Yilan County, Taiwan., Lee YT; School of Medicine, Chung Shan Medical University, Taichung, Taiwan., Syu YL; Infection Control Office, Hua-Lien Hospital, Ministry of Health and Welfare, Hualien, Taiwan., Hsu GJ; Department of Internal Medicine, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chiayi, Taiwan., Chen YC; Center for Infection Control, National Taiwan University Hospital, Taipei, Taiwan., Lee NY; Division of Infectious Disease, Department of Internal Medicine and Center for Infection Control, National Cheng Kung University Hospital, Tainan, Taiwan., Chen CH; Section of Infectious Diseases, Department of Internal Medicine, Changhua Christian Hospital, Changhua County, Taiwan., Yang CC; Department of Infectious Diseases, Kuang Tien General Hospital, Taichung, Taiwan., Wang LS; Division of Infectious Diseases, Department of Internal Medicine, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan., Liu JW; Division of Infectious Diseases, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan., Kao CC; Division of Infectious Disease, Department of Internal Medicine, Tungs' Taichung Metroharbor Hospital, Taichung, Taiwan., Chang YT; Division of Infectious Diseases, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan., Liu KS; Division of Infectious Diseases, Department of Internal Medicine, Show Chwan Memorial Hospital, Changhua, Taiwan., Hu BS; Section of Infectious Diseases, Department of Internal Medicine, Taipei City Hospital, Heping Branch, Taipei, Taiwan., Hsu CH; Division of Infectious Diseases, Cheng Ching Hospital Chung Kang Branch, Taichung, Taiwan., Huang YC; Division of Infectious Diseases, Jen-Ai Hospital, Taichung, Taiwan., Lo HJ; Taiwan Mycology Reference Center, National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Miaoli County, Taiwan; Department of Biological Science and Technology, National Yang Ming Chiao Tung University, Hsinchu, Taiwan; School of Dentistry, China Medical University, Taichung, Taiwan. Electronic address: hjlo@nhri.edu.tw.
Jazyk:	angličtina
Zdroj:	Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi [J Microbiol Immunol Infect] 2024 Aug 31. Date of Electronic Publication: 2024 Aug 31.
DOI:	10.1016/j.jmii.2024.08.011
Abstrakt:	Background: A predominate azole-resistant Candida tropicalis clade 4 genotype causing candidemia has been detected in not only Taiwan but also China, Singapore, and Australia. It can also be detected on fruit surfaces. In addition to determining distribution and drug susceptibilities of pathogenic yeasts in environments of intensive care units of 25 hospitals in Taiwan, we would also like to investigate whether the azole-resistant C. tropicalis exists in Taiwan's hospital environment. Methods: The swabs of hospital environments were collected from August to November in 2020 and were cultured for yeasts. The yeasts were identified by rDNA sequence and the antifungal susceptibilities of those isolates were determined by the broth microdilution method. Results: The average yeast-culture rate of hospitals was 9.4% (217/2299). Sinks had the highest yeast-positive culture rate (32.7%), followed by bedside tables (28.9%), floors (26.0%), water-dispenser buttons (23.8%), and TV controller/touch panels (19.0%). Of 262 identified isolates, Candida parapsilosis was the most common species, accounting for 22.1%, followed by Filobasidium uniguttulatum (18.3%), Candida albicans (9.5%), C. tropicalis (8.0%), Candida glabrata (Nakaseomyces glabratus) (6.9%), and 30 other species (35.1%). Of the 21 C. tropicalis isolates from 11 units in 9 hospitals, 15 diploid sequence types (DSTs) were identified. The two DST506 fluconazole-resistant ones belonged to clade 4. Conclusion: We detected not only various pathogenic yeast species but also the predominant clade 4 genotype of azole-resistant C. tropicalis. Our findings highlight and re-emphasize the importance of regular cleaning and disinfection practices. Competing Interests: Declaration of competing interest The authors declare no conflict of interests. (Copyright © 2024. Published by Elsevier B.V.)
Databáze:	MEDLINE
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