Novel deep-learning analysis for connective tissue disease -related interstitial lung disease extent assessment on CT: a preliminary cross-sectional study.

Autor:	Ito Y; Centre for Rheumatic Diseases, Mie University Hospital, 2-174 Edobashi, Tsu, 514-8507, Japan, Tel: +81-59-231-5729., Ichikawa Y; Department of Radiology, Mie University Hospital, 2-174 Edobashi, Tsu, 514-8507, Japan, Tel: +81-59-231-1111., Murashima S; Department of Radiology, Mie University Hospital, 2-174 Edobashi, Tsu, 514-8507, Japan, Tel: +81-59-231-1111., Sakuma H; Department of Radiology, Mie University Hospital, 2-174 Edobashi, Tsu, 514-8507, Japan, Tel: +81-59-231-1111., Iwasawa T; Department of Radiology, Kanagawa Cardiovascular and Respiratory Centre, 6-16-1, Tomiokahigashi, Kanazawa-ku, Yokohama, 236-0051, Japan, Tel: +81-45-701-9581., Arinuma Y; Centre for Rheumatic Diseases, Mie University Hospital, 2-174 Edobashi, Tsu, 514-8507, Japan, Tel: +81-59-231-5729., Nakajima A; Centre for Rheumatic Diseases, Mie University Hospital, 2-174 Edobashi, Tsu, 514-8507, Japan, Tel: +81-59-231-5729.
Jazyk:	angličtina
Zdroj:	Rheumatology (Oxford, England) [Rheumatology (Oxford)] 2024 Sep 13. Date of Electronic Publication: 2024 Sep 13.
DOI:	10.1093/rheumatology/keae491
Abstrakt:	Objectives: Physician's evaluation of interstitial lung disease (ILD) extension with high-resolution computed tomography (HRCT) has limitations such as lack of objectivity and reproducibility. This study aimed to investigate the utility of computer-based deep-learning analysis using QZIP-ILD® software (DL-QZIP) compared with conventional approaches in connective tissue disease (CTD) -related ILD. Methods: Patients with CTD-ILD visiting our Rheumatology Centre between December 2020 and April 2024 were recruited. Quantitative scores, including the percentage of lung involvement in ground-glass opacity (QGG), total fibrotic lesion (QFIB), and overall ILD extension encompassing both QGG and QFIB (QILD), calculated by DL-QZIP, were compared with semiquantitative visual method, employing intraclass correlation coefficients (ICC). We compared the capability of QILD scores to distinguish patients with forced vital capacity (FVC) % <70 in both methods determined by the area under the curve (AUC) by the receiver-operating characteristic curve analysis and DeLong's test. Results: Eighty patients (median age, 66 years; 14 men) were included. Median QGG, QFIB, and QILD scores were 3.45%, 2.19%, and 5.35% using DL-QZIP, and 3.25%, 4.06%, and 8.48% using visual method, respectively. Correlations between DL-QZIP and visual method were 0.75 for QGG, 0.61 for QFIB, and 0.75 for QILD. The AUC of QILD scores for FVC% <70 was significantly higher with DL-QZIP (0.833) compared with visual method (0.660) (p < 0.01). Conclusion: QZIP-ILD® demonstrates superior capability in distinguishing patients with a radiological scenario correlated to severe physiological impairment, while showing relatively good correlations in quantifying the extent on HRCT compared with conventional method in CTD-ILD. (© The Author(s) 2024. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For permissions, please email: journals.permissions@oup.com.)
Databáze:	MEDLINE
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