Mediated relationship between Vitamin D deficiency and reduced pulmonary function by copper in Taiwanese young adults.

Autor: Chen CW; Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei, Taiwan, ROC; Division of Cardiology, Department of Internal Medicine, National Taiwan, University Hospital Yunlin Branch, Yunlin, Taiwan, ROC., Shu CC; Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan, ROC., Han YY; Department of Anesthesiology, National Taiwan University Hospital, Taipei, Taiwan, ROC; Department of Traumatology, National Taiwan University Hospital, Taipei, Taiwan, ROC., Hsu SH; Department of Laboratory Medicine, College of Medicine, National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan, ROC., Hwang JS; Institute of Statistical Science, Academia Sinica, Taipei, Taiwan, ROC., Su TC; Department of Environmental and Occupational Medicine, National Taiwan University Hospital, Taipei, Taiwan, ROC; Institute of Environmental and Occupational Health Sciences, College of Public Health, National Taiwan University, Taipei, Taiwan, ROC; Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan, ROC. Electronic address: tachensu@gmail.com.
Jazyk: angličtina
Zdroj: Ecotoxicology and environmental safety [Ecotoxicol Environ Saf] 2024 Oct 15; Vol. 285, pp. 117034. Date of Electronic Publication: 2024 Sep 12.
DOI: 10.1016/j.ecoenv.2024.117034
Abstrakt: Background: Vitamin D deficiency is prevalent worldwide and associated with worse outcomes in various lung diseases. This study examines the association between vitamin D deficiency and pulmonary function in healthy young adults.
Methods: This prospective cohort study (2017-2019) explored the impact of vitamin D deficiency on pulmonary function in a community-based young adult population. Pulmonary function was assessed via spirometry, with serum 25-hydroxyvitamin D [25(OH)D] and urinary copper levels quantified. Multivariate regression was used to estimate the relationship between vitamin D levels and lung function, with mediation analysis evaluating copper's role.
Results: The study included 1034 participants, average age 33.45 years, 41.93 % male. The median 25(OH)D level was 19.20 ng/mL (Interquartile Range: 13.48-24.90 ng/mL). Over half (54.74 %) had 25(OH)D levels below 20 ng/mL. Higher 25(OH)D levels were associated with better forced vital capacity (FVC) and forced expiratory volume in one second (FEV₁). Trends suggested subgroup differences, but these were not statistically significant, indicating a consistent effect of 25(OH)D on pulmonary function across groups. SEM analysis suggested urinary copper as a mediator between 25(OH)D levels and FVC.
Conclusion: Vitamin D deficiency is significantly associated with reduced pulmonary function in young adults in Taiwan.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper
(Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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