Influence of the Onset of Menopause on the Risk of Developing Alzheimer's Disease.

Autor:	Briceno Silva G; Obstetrics and Gynecology, Universidad de Oriente, Barcelona, VEN., Arvelaez Pascucci J; Infectious Disease, Universidad Central de Venezuela, Caracas, VEN., Karim H; Internal Medicine, Istanbul Medipol University, Istanbul, TUR., Kaur G; Neurosurgery, Institute of Human Behaviour and Allied Sciences, New Delhi, IND., Olivas Lerma R; General Practice, Universidad Autonoma de Chihuahua, Chihuahua, MEX., Mann AK; General Practice, Government Medical College Amritsar, Amritsar, IND., Gnanasekaran S; Internal Medicine, New York Medical College, St. Mary's and St. Clare's Hospital, Passaic, USA., Thomas Garcia KD; General Practice, Universidad de Oriente, Barcelona, VEN.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2024 Sep 10; Vol. 16 (9), pp. e69124. Date of Electronic Publication: 2024 Sep 10 (Print Publication: 2024).
DOI:	10.7759/cureus.69124
Abstrakt:	Menopause is a natural phase marked by the permanent cessation of menstrual cycles, occurring when the production of reproductive hormones from the ovaries stops for at least 12 consecutive months. Studies have suggested a potential connection between menopause and a heightened risk of developing Alzheimer's disease (AD), underscoring the significant role of reduced estrogen levels in the development of AD. Estrogen plays a crucial role in brain metabolism, influencing energy metabolism, synaptic plasticity, and cognitive functions. The cognitive benefits associated with hormone replacement therapy (HRT) are believed to be linked to estrogen's neuroprotective effects, either through direct action on the brain or indirectly by improving cardiovascular health. Extensive literature supports the positive impact of estrogen on brain cells. While the physiological effects of estrogen on the brain have not been consistently replicated in clinical trials, further research is crucial to provide more definitive recommendations to menopausal patients regarding the influence of HRT on AD. This review aims to comprehensively explore the interplay between menopause and AD, as well as the potential of HRT to mitigate cognitive decline in post-menopausal individuals. Competing Interests: Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. (Copyright © 2024, Briceno Silva et al.)
Databáze:	MEDLINE
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