Dynamics of gas exchange and heart rate signal entropy in standard cardiopulmonary exercise testing during critical periods of growth and development.

Autor: Blanks Z; School of Data Science, University of Virginia, Charlottesville, Virginia, USA., Brown DE; School of Data Science, University of Virginia, Charlottesville, Virginia, USA., Cooper DM; Institute for Clinical and Translational Science, University of California, Irvine, California, USA., Aizik SR; Department of Pediatrics, Pediatric Exercise and Genomics Research Center, University of California, Irvine, California, USA., Bar-Yoseph R; Department of Pediatrics, Pediatric Exercise and Genomics Research Center, University of California, Irvine, California, USA.; Pediatric Pulmonary Institute, Ruth Rappaport Children's Hospital, Rambam Health Care Campus, Haifa, Israel.
Jazyk: angličtina
Zdroj: Physiological reports [Physiol Rep] 2024 Sep; Vol. 12 (17), pp. e70034.
DOI: 10.14814/phy2.70034
Abstrakt: Standard cardiopulmonary exercise testing (CPET) produces a rich dataset but its current analysis is often limited to a few derived variables such as maximal or peak oxygen uptake (V̇O 2 ). We tested whether breath-by-breath CPET data could be used to determine sample entropy (SampEn) in 81 healthy children and adolescents (age 7-18 years old, equal sex distribution). To overcome challenges of the relatively small time-series CPET data size and its nonstationarity, we developed a Python algorithm for short-duration physiological signals. Comparing pre- and post-ventilatory threshold (VT 1 ) CPET phases, we found: (1) SampEn decreased by 9.46% for V̇O 2 and 5.01% for V̇CO 2 (p < 0.05), in the younger, early-pubertal participants; and (2) HR SampEn fell substantially by 70.8% in the younger and 77.5% in the older participants (p < 0.001). Across all ages, females exhibited greater HR SampEn than males during both pre- and post VT 1 CPET phases by 14.10% and 23.79%, respectively, p < 0.01. In females, late-pubertal had 17.6% lower HR SampEn compared to early-pubertal participants (p < 0.05). Breath-by-breath gas exchange and HR data from CPET are amenable to SampEn analysis that leads to novel insight into physiological responses to work intensity, and sex and maturational effects.
(© 2024 The Author(s). Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society.)
Databáze: MEDLINE
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