Effect of D,L methionine and ammonium chloride on urine acidification, urinary fractional excretion of calcium, and blood bicarbonate in clinically healthy goats.

Autor:	Neal CE; Department of Large Animal Clinical Sciences, University of Tennessee, Knoxville, TN., Grissett GP; Department of Pathobiology and Population Medicine, Mississippi State University, Starkville, MS., Fleming S; Department of Pathobiology and Population Medicine, Mississippi State University, Starkville, MS., Wills RW; Department of Pathobiology and Population Medicine, Mississippi State University, Starkville, MS., Woolums AR; Department of Pathobiology and Population Medicine, Mississippi State University, Starkville, MS.
Jazyk:	angličtina
Zdroj:	American journal of veterinary research [Am J Vet Res] 2024 Sep 10; Vol. 85 (11). Date of Electronic Publication: 2024 Sep 10 (Print Publication: 2024).
DOI:	10.2460/ajvr.24.04.0097
Abstrakt:	Background: Urinary acidification with ammonium chloride (AC) for urolith dissolution is a common treatment for goats with urolithiasis. Studies have reported increased fractional excretion of calcium (FECa) following AC administration, which could increase calcium-based urolithiasis. D,L methionine (MET) may result in similar acidification with less calcium excretion. Objective: To compare the effects of orally administered MET and AC on urine and blood pH, FECa, and blood HCO3- concentrations in male goats. Methods: Prospective, randomized, crossover study. 12 healthy, 5-to-6-month-old Boer-cross wethers were administered 200 mg/kg of AC or MET orally for 14 days with a 7-day washout period between trials. Venous blood and urine samples were collected every 2 days. The effects of treatment and treatment day on urine and blood pH, HCO3-, and FECa were assessed using linear mixed models. Results: Ammonium chloride and MET lowered least squares means (LSM) urine pH on day 6 (LSM, 7.49; 95% CI, 6.44 to 8.54), 8 (LSM, 7.78; 95% CI, 6.73 to 8.83), and 10 (LSM, 7.53; 95% CI, 6.49 to 8.58) when compared to day 0 (LSM, 8.23; 95% CI, 7.18 to 9.28). Some goats' urine indicated acidification (pH < 7.0) in the first phase of the trial; however, for the entire trial, a significant treatment effect was not detected on urine pH, blood pH, blood HCO3- or log10 FECa. Clinical Relevance: Ammonium chloride and MET acidified urine of some goats. Dietary cation-anion difference should be considered when treating healthy goats to acidify their urine.
Databáze:	MEDLINE
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