Prevalence of cardiovascular events among transgender adults with obesity: A population-based analysis.

Autor:	Pingili A; Department of Internal Medicine, MedStar Union Memorial Hospital, Baltimore, MD, USA., Vempati R; Department of Internal Medicine, Trinity Health Oakland Hospital, Pontiac, MI, USA., Vemula M; Department of General Medicine, Malla Reddy Institute of Medical Sciences, Hyderabad, Telangana, India., Lakkimsetti M; Department of General Medicine, Mamata Medical College, Khammam, Telangana, India., Madhavaram H; Department of Internal Medicine, Morristown Medical Centre, Morristown, NJ, USA., Nanjundappa A; Department of Medicine, MedStar Franklin Square Medical Centre, Baltimore, MD, USA., Gummadi J; Department of Medicine, MedStar Franklin Square Medical Centre, Baltimore, MD, USA., Singh S; University Hospitals of North Midlands MHS Trust, Stroke-on-Trent, UK., Desai R; Independent Researcher, Outcomes Research, Atlanta, GA, USA., Sunkara P; Department of Internal Medicine, Passion Health Primary Care, Denton, TX, USA.
Jazyk:	angličtina
Zdroj:	Obesity pillars [Obes Pillars] 2024 Aug 13; Vol. 11, pp. 100125. Date of Electronic Publication: 2024 Aug 13 (Print Publication: 2024).
DOI:	10.1016/j.obpill.2024.100125
Abstrakt:	Introduction: Although obesity and its impact on cardiovascular (CV) events have been extensively studied in the cisgender population, little is known about its impact on CV events in transgender individuals. Our study aimed to establish the prevalence of obesity and CV events in transgender adults. Methods: We conducted a retrospective cohort comparative study utilizing the U.S. National Inpatient Sample 2020 database. We identified admissions of transgender patients with administrative codes. Later, these patients were divided into obesity and non-obesity cohorts. Multivariable regression analysis was then performed for in-hospital all-cause mortality, acute myocardial infarction, acute ischemic stroke, cardiac arrest, pulmonary embolism and, major adverse cardiovascular and cerebrovascular events (MACCE). Results: In 2020, 19,345 transgender patients were admitted; 16,390 (84.7 %) had no obesity, and 2,955 (15.3 %) had obesity. The median age was 31 years in the non-obesity cohort and 37 years in the obesity cohort. Transgender men comprised 54.5 % of the non-obesity cohort and 47.9 % of the obesity cohort. Common baseline conditions in the non-obesity and obesity cohorts, respectively, included hypertension (20.7 % vs. 43.5 %), diabetes (10.2 % vs. 32.5 %), chronic pulmonary disease (18.9 % vs. 27.7 %), and hyperlipidemia (11.5 % vs. 25 %). MACCE was observed in 2.3 % of the non-obesity cohort compared to 5.4 % in the obesity cohort, and cardiac arrest occurred in 0.2 % of the non-obesity cohort versus 1.2 % in the obesity cohort. A statistically significant association was found in MACCE [odds ratio (OR) 2.1, 95 % confidence interval (CI) 1.24-3.55, p = 0.006] and cardiac arrest [OR 3.92, 95 % CI 1.11-12.63, p = 0.022] among transgender patients with obesity. Conclusion: We observed increased odds of MACCE and cardiac arrest in transgender patients with obesity, possibly due to obesity and CV risk factors like hypertension, diabetes, and hyperlipidemia. Further large-scale comparative studies are needed to better understand obesity's impact on CV outcomes in the transgender population. Competing Interests: None. (© 2024 The Author(s).)
Databáze:	MEDLINE
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