Rare Hybrid Perineurioma and Granular Cell Tumor: A Pediatric Case.

Autor:	Sun KH; Division of Plastic and Reconstructive Surgery, Children's National Hospital, Washington, DC, USA.; Division of Pathology and Laboratory Medicine, Children's National Hospital, Washington, DC, USA., Goyal SP; Division of Plastic and Reconstructive Surgery, Children's National Hospital, Washington, DC, USA.; Division of Pathology and Laboratory Medicine, Children's National Hospital, Washington, DC, USA., Kim EM; Division of Plastic and Reconstructive Surgery, Children's National Hospital, Washington, DC, USA., Mantilla-Rivas E; Division of Plastic and Reconstructive Surgery, Children's National Hospital, Washington, DC, USA., Rogers GF; Division of Plastic and Reconstructive Surgery, Children's National Hospital, Washington, DC, USA., Gulino SP; Division of Pathology and Laboratory Medicine, Children's National Hospital, Washington, DC, USA.
Jazyk:	angličtina
Zdroj:	Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society [Pediatr Dev Pathol] 2024 Sep 09, pp. 10935266241274529. Date of Electronic Publication: 2024 Sep 09.
DOI:	10.1177/10935266241274529
Abstrakt:	We present a case of a 13-year-old patient with a distinct tumor with both granular cell and perineurial elements, located on the lower lip. The patient presented with a long-standing lip mass that was clinically felt to most likely represent a mucocele. Following surgical excision, histopathological examination revealed a well-circumscribed tumor composed of granular cells with positive S100 protein staining and spindled cells positive for EMA and GLUT-1, confirming mixed neuroectodermal and perineurial origin. This is the first case documenting a perineurial-granular cell hybrid tumor in a patient under 18 years old, and the first to be reported in the head and neck. This case expands our understanding of hybrid PNSTs, emphasizing the importance of considering diverse clinical presentations, especially in the context of rare pediatric occurrences in atypical locations. Competing Interests: Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Databáze:	MEDLINE
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