An Unusual and Discrepant Presentation of a Skull Base Paraganglioma.

Autor:	Patel R; Otolaryngology, Loyola University Medical Center, Maywood, USA., Allam YA; Anatomical Sciences, University of Michigan, Ann Arbor, USA., Shukairy MK; Otolaryngology, Loyola University Medical Center, Maywood, USA., Kircher M; Otolaryngology, Loyola University Medical Center, Maywood, USA.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2024 Aug 07; Vol. 16 (8), pp. e66394. Date of Electronic Publication: 2024 Aug 07 (Print Publication: 2024).
DOI:	10.7759/cureus.66394
Abstrakt:	Paragangliomas are rare tumors of neuroendocrine origin. Within the head and neck, these tumors are slow-growing and locally destructive, with a small malignant potential. Vagal paragangliomas (VPs) originate from paraganglia around the vagus nerve, typically at the level of the skull base. Cranial nerve deficits are common at presentation, with the vagus nerve and hypoglossal nerves being most affected. Similarly, hypoglossal paragangliomas (HPs) originate from around the hypoglossal nerve but are extremely rare and less documented. We describe the case of a patient presenting with an isolated hypoglossal nerve palsy in the setting of a tumor that radiologically represents a VP. A descriptive literature review was conducted to highlight presentation, management, and outcomes related to this pathology. A 65-year-old male presented to the clinic with tongue fasciculations and several years of dysarthria. Physical examination showed intermittent right tongue fasciculations in addition to ipsilateral hemi-atrophy. A computed tomography scan with contrast revealed an enhancing skull base mass inferior to the right carotid space. Subsequently, magnetic resonance imaging with contrast further delineated its anatomic involvement and site of origin, allowing for the diagnosis of a VP. After further discussion with the patient about his clinical findings, the decision was made to proceed with observation and serial imaging. Skull base paragangliomas are a rare pathologic entity that may pose a challenging multidisciplinary approach to optimize management strategies. Treatment may vary on a case-by-case basis and is dependent on patient and tumor characteristics. Competing Interests: Human subjects: Consent was obtained or waived by all participants in this study. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. (Copyright © 2024, Patel et al.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu