Periodic Flows in Microfluidics.

Autor: Mudugamuwa A; Queensland Micro and Nanotechnology Centre, Griffith University, Brisbane, QLD, 4111, Australia., Roshan U; Queensland Micro and Nanotechnology Centre, Griffith University, Brisbane, QLD, 4111, Australia., Hettiarachchi S; Queensland Micro and Nanotechnology Centre, Griffith University, Brisbane, QLD, 4111, Australia., Cha H; Queensland Micro and Nanotechnology Centre, Griffith University, Brisbane, QLD, 4111, Australia., Musharaf H; Queensland Micro and Nanotechnology Centre, Griffith University, Brisbane, QLD, 4111, Australia., Kang X; Queensland Micro and Nanotechnology Centre, Griffith University, Brisbane, QLD, 4111, Australia., Trinh QT; Queensland Micro and Nanotechnology Centre, Griffith University, Brisbane, QLD, 4111, Australia., Xia HM; School of Mechanical Engineering, Nanjing University of Science and Technology, Nanjing, 210094, P. R. China., Nguyen NT; Queensland Micro and Nanotechnology Centre, Griffith University, Brisbane, QLD, 4111, Australia., Zhang J; Queensland Micro and Nanotechnology Centre, Griffith University, Brisbane, QLD, 4111, Australia.; School of Engineering and Built Environment, Griffith University, Brisbane, QLD, 4111, Australia.
Jazyk: angličtina
Zdroj: Small (Weinheim an der Bergstrasse, Germany) [Small] 2024 Sep 09, pp. e2404685. Date of Electronic Publication: 2024 Sep 09.
DOI: 10.1002/smll.202404685
Abstrakt: Microfluidics, the science and technology of manipulating fluids in microscale channels, offers numerous advantages, such as low energy consumption, compact device size, precise control, fast reaction, and enhanced portability. These benefits have led to applications in biomedical assays, disease diagnostics, drug discovery, neuroscience, and so on. Fluid flow within microfluidic channels is typically in the laminar flow region, which is characterized by low Reynolds numbers but brings the challenge of efficient mixing of fluids. Periodic flows are time-dependent fluid flows, featuring repetitive patterns that can significantly improve fluid mixing and extend the effective length of microchannels for submicron and nanoparticle manipulation. Besides, periodic flow is crucial in organ-on-a-chip (OoC) for accurately modeling physiological processes, advancing disease understanding, drug development, and personalized medicine. Various techniques for generating periodic flows have been reported, including syringe pumps, peristalsis, and actuation based on electric, magnetic, acoustic, mechanical, pneumatic, and fluidic forces, yet comprehensive reviews on this topic remain limited. This paper aims to provide a comprehensive review of periodic flows in microfluidics, from fundamental mechanisms to generation techniques and applications. The challenges and future perspectives are also discussed to exploit the potential of periodic flows in microfluidics.
(© 2024 The Author(s). Small published by Wiley‐VCH GmbH.)
Databáze: MEDLINE
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