Association of Borrelia burgdorferi with nuchal bursitis and elevated outer surface protein A-specific serum antibodies in horses of the northeastern United States.

Autor:	Pearson EK; 1Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY., Guarino C; 2Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY., Cercone M; 1Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY., Divers T; 1Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY., Lambert J; 3Department of Clinical Sciences, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA., García-López J; 4Department of Clinical Studies, New Bolton Center, School of Veterinary Medicine, University of Pennsylvania, Kennett Square, PA., Johnson AL; 4Department of Clinical Studies, New Bolton Center, School of Veterinary Medicine, University of Pennsylvania, Kennett Square, PA., Engiles JB; 4Department of Clinical Studies, New Bolton Center, School of Veterinary Medicine, University of Pennsylvania, Kennett Square, PA.; 5Department of Pathobiology, New Bolton Center, School of Veterinary Medicine, University of Pennsylvania, Kennett Square, PA., Marconi R; 6Department of Microbiology and Immunology, School of Medicine, Virginia Commonwealth University, Richmond, VA., Smith J; 6Department of Microbiology and Immunology, School of Medicine, Virginia Commonwealth University, Richmond, VA., Brown K; 4Department of Clinical Studies, New Bolton Center, School of Veterinary Medicine, University of Pennsylvania, Kennett Square, PA., Pinn-Woodcock T; 2Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY.
Jazyk:	angličtina
Zdroj:	Journal of the American Veterinary Medical Association [J Am Vet Med Assoc] 2024 Sep 06; Vol. 262 (11), pp. 1476-1484. Date of Electronic Publication: 2024 Sep 06 (Print Publication: 2024).
DOI:	10.2460/javma.24.05.0312
Abstrakt:	Objective: Evaluate the incidence of Borrelia burgdorferi in cases of equine nuchal bursitis (NB) and investigate the relationship between elevated serum outer surface protein A (OspA) antibodies and the molecular identification of B burgdorferi in bursal tissue or synovial fluid. Additionally, describe clinical cases and compare the histologic changes in NB with and without detection of B burgdorferi. Methods: This was a retrospective multicenter cohort study (2013 to 2022). Medical records from horses with a diagnosis of NB and B burgdorferi PCR testing on NB tissue or synovial fluid were reviewed. The study population included 11 horses with a postmortem diagnosis of NB, 19 horses from the northeastern US with an antemortem diagnosis of B burgdorferi PCR-positive NB, and 15 healthy controls without evidence of NB and unvaccinated for B burgdorferi. Where serum was available, Lyme multiplex assay results were compared with controls and ELISAs targeting individual B burgdorferi antigens were performed. Histologic findings in nuchal bursa tissue were compared between NB cases with and without B burgdorferi PCR detection. Results: Serum OspA antibody values in B burgdorferi-positive NB cases (n = 13) were significantly elevated (P < .001) compared to controls (15), and OspA was the predominant antigen detected by ELISA (8). Histopathology did not vary between NB cases with (n = 9) and without (6) B burgdorferi PCR detection. Conclusions: The presence of B burgdorferi in the nuchal bursa of horses is associated with increased serum OspA antibodies. Clinical Relevance: The role of B burgdorferi in equine NB may be underestimated, and targeted therapy requires investigation.
Databáze:	MEDLINE
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