Lifetime physical activity influences Parkinson's disease progression.

Autor: Hu YC; Department of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, CA, USA., Kusters CDJ; Department of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, CA, USA; Cousins Center for Psychoneuroimmunology, University of California, Los Angeles, Los Angeles, CA, USA; Jane and Terry Semel Institute for Neuroscience and Human Behavior, Department of Psychiatry & Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, CA, USA., Paul KC; Department of Neurology, UCLA David Geffen School of Medicine, Los Angeles, CA, USA., Folle AD; Department of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, CA, USA., Zhang K; Department of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, CA, USA., Shih IF; Department of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, CA, USA., Keener AM; Department of Neurology, UCLA David Geffen School of Medicine, Los Angeles, CA, USA; Parkinson's Disease Research, Education, and Clinical Center, VA Greater Los Angeles Healthcare System, Los Angeles, CA, USA., Bronstein JM; Department of Neurology, UCLA David Geffen School of Medicine, Los Angeles, CA, USA., Ritz BR; Department of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, CA, USA; Department of Neurology, UCLA David Geffen School of Medicine, Los Angeles, CA, USA; Department of Environmental Health Sciences, UCLA Fielding School of Public Health, Los Angeles, CA, USA. Electronic address: britz@ucla.edu.
Jazyk: angličtina
Zdroj: Parkinsonism & related disorders [Parkinsonism Relat Disord] 2024 Aug 31; Vol. 128, pp. 107122. Date of Electronic Publication: 2024 Aug 31.
DOI: 10.1016/j.parkreldis.2024.107122
Abstrakt: Introduction: Past studies suggested that Parkinson's disease (PD) patients who engage in physical activity (PA) after diagnosis have slower motor progression. Here, we examine the influence of lifetime PA prior to PD onset on motor, cognitive, and overall functional decline among PD patients.
Methods: For 495 participants in the Parkinson's Environment and Gene (PEG) studies, we collected PA-related measures through interviews and quantified these using metabolic equivalents (MET) scores. PD progression was defined as time to a Unified Parkinson's Disease Rating Scale Part III (UPDRS-III) conversion to ≥ 35 points, Hoehn and Yahr (H&Y) ≥ 3, and a 4-point decline in Mini-Mental State Examination (MMSE). We used Cox frailty models to estimate hazard ratios and inverse probability weights to account for heterogeneity by enrollment wave and censoring.
Results: For PD patients reporting the highest lifetime strenuous MET-h/wk (highest quartile), we estimated a lower HR for time-to-UPDRS-III-conversion (Q4 vs. Q1: HR = 0.56, 95 % CI = [0.36, 0.87]). Additionally, having engaged in any competitive sport also reduced the risk of reaching a UPDRS-III ≥ 35 points (low vs. none: HR = 0.61, 95 % CI = [0.44, 0.86]; high vs. none: HR = 0.63; 95 % CI = [0.44,0.86]); high levels of sports activities also affected progression on the H&Y scale (high vs. none: HR = 0.73; 95 % CI = [0.46,1.00]). Lifetime PA measures did not affect time-to-MMSE decline.
Conclusion: Our study suggests that PD patients who engaged in higher levels of lifetime strenuous PA and competitive sports prior to PD diagnosis experience slower motor and overall functional decline, suggesting that lifetime PA may contribute to a physical reserve advantageous for PD patients.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024. Published by Elsevier Ltd.)
Databáze: MEDLINE
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