Metabolomic profiling of elite female soccer players: urinary biomarkers over a championship season.

Autor: Gouveia MMS; Post-Graduate Nutrition Program, Faculty of Nutrition, Federal University of Alagoas, Maceió, Brazil., do Nascimento MBA; Post-Graduate Nutrition Program, Faculty of Nutrition, Federal University of Alagoas, Maceió, Brazil., Crispim AC; Nuclear Magnetic Resonance Analysis and Research Nucleus, Institute of Chemistry and Biotechnology (IQB) of the Federal University of Alagoas, Macéio, Brazil., da Rocha ER Jr; Nuclear Magnetic Resonance Analysis and Research Nucleus, Institute of Chemistry and Biotechnology (IQB) of the Federal University of Alagoas, Macéio, Brazil., Dos Santos MPP; Laboraty of Applied Sports Science, Institute of Physical Educatition and Sports, Federal University of Alagoas, Macéio, Brazil., Bento ES; Nuclear Magnetic Resonance Analysis and Research Nucleus, Institute of Chemistry and Biotechnology (IQB) of the Federal University of Alagoas, Macéio, Brazil., De Aquino TM; Nuclear Magnetic Resonance Analysis and Research Nucleus, Institute of Chemistry and Biotechnology (IQB) of the Federal University of Alagoas, Macéio, Brazil., Balikian P Jr; Laboraty of Applied Sports Science, Institute of Physical Educatition and Sports, Federal University of Alagoas, Macéio, Brazil., Rodrigues NA; Laboraty of Applied Sports Science, Institute of Physical Educatition and Sports, Federal University of Alagoas, Macéio, Brazil., Ataide-Silva T; Post-Graduate Nutrition Program, Faculty of Nutrition, Federal University of Alagoas, Maceió, Brazil.; Laboraty of Applied Sports Science, Institute of Physical Educatition and Sports, Federal University of Alagoas, Macéio, Brazil., de Araujo GG; Post-Graduate Nutrition Program, Faculty of Nutrition, Federal University of Alagoas, Maceió, Brazil.; Laboraty of Applied Sports Science, Institute of Physical Educatition and Sports, Federal University of Alagoas, Macéio, Brazil., Sousa FAB; Post-Graduate Nutrition Program, Faculty of Nutrition, Federal University of Alagoas, Maceió, Brazil. filipe.sousa@iefe.ufal.br.; Laboraty of Applied Sports Science, Institute of Physical Educatition and Sports, Federal University of Alagoas, Macéio, Brazil. filipe.sousa@iefe.ufal.br.
Jazyk: angličtina
Zdroj: Metabolomics : Official journal of the Metabolomic Society [Metabolomics] 2024 Sep 05; Vol. 20 (5), pp. 101. Date of Electronic Publication: 2024 Sep 05.
DOI: 10.1007/s11306-024-02164-5
Abstrakt: Introduction: In soccer, most studies evaluate metabolic profile changes in male athletes, often using data from a single match. Given the current landscape of women's soccer and the effects of biological sex on the physiological response and adaptation to exercise, more studies targeting female athletes and analyzing pre- and post-game moments throughout the season are necessary.
Objectives: To describe the metabolomics profile of female soccer athletes from an elite team in Brazil. The study observed the separation of groups in three pre- and post-game moments and identified the discriminating metabolites.
Methods: The study included 14 female soccer athletes. Urine samples were collected and analyzed using Nuclear Magnetic Resonance in pre-game and immediate post-game moments over three national championship games. The metabolomics data were then used to generate OPLS-DA and VIP plots.
Results: Forty-three metabolites were identified in the samples. OPLS-DA analyses demonstrated a progressive separation between pre-post conditions, as supported by an increasing Q 2 value (0.534, 0.625, and 0.899 for games 1, 2 and 3, respectively) and the first component value (20.2% and 19.1% in games 1 and 2 vs. 29.9% in game 3). Eight out of the fifteen most discriminating metabolites appeared consistently across the three games: glycine, formate, citrate, 3-hydroxyvalerate, glycolic acid, trimethylamine, urea, and dimethylglycine.
Conclusion: The main difference between the three games was the increasing separation between groups throughout the championship. Since the higher VIP-scores metabolites are linked to energy and protein metabolism, this separation may be attributed several factors, one being the accumulation of fatigue.
(© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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