Infiltrating Ductal Breast Carcinoma in a Male Patient With Associated BARD1 Mutation.

Autor:	McGrath J; Dr. Kiran C. Patel College of Osteopathic Medicine, Nova Southeastern University, Davie, USA., Rhatigan DJ; Dr. Kiran C. Patel College of Osteopathic Medicine, Nova Southeastern University, Davie, USA., Donahue D; Dr. Kiran C. Patel College of Osteopathic Medicine, Nova Southeastern University, Davie, USA., Fannin M; Dr. Kiran C. Patel College of Osteopathic Medicine, Nova Southeastern University, Davie, USA., Lawson N; General Surgery, Palmetto General Hospital, Miami, USA.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2024 Aug 05; Vol. 16 (8), pp. e66216. Date of Electronic Publication: 2024 Aug 05 (Print Publication: 2024).
DOI:	10.7759/cureus.66216
Abstrakt:	Male breast cancer is an uncommon diagnosis with limited research on management and prognosis due to its rarity. We discuss a case of a 55-year-old male with a non-contributory past medical history who presented with an enlarging palpable mass of his right breast tissue at the 10:00 position. The ultrasound of the right breast showed a 2.8 cm heterogenous mass with irregular borders highly suspicious for malignancy. The follow-up sonogram-guided core biopsy was performed, and the pathology of the mass confirmed high-grade infiltrating ductal carcinoma. A modified radical mastectomy of the right breast with extensive axillary lymph node excision was performed. Genetic testing of the excised tumor revealed a MUTYH gene mutation and a BARD1 (BRCA1-associated RING domain 1) gene mutation of unknown significance. Histopathological analysis confirmed a Grade 2, ER/PR-positive, KI 67-positive, and HER2-negative tumor. Competing Interests: Human subjects: Consent was obtained or waived by all participants in this study. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. (Copyright © 2024, McGrath et al.)
Databáze:	MEDLINE
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