Examining associations between brain morphology in late childhood and early alcohol or tobacco use initiation in adolescence: Findings from a large prospective cohort.

Autor: Boer OD; Center for Substance Use and Addiction Research (CESAR), Department of Psychology, Education and Child Studies, Erasmus School of Social and Behavioral Science, Erasmus University Rotterdam, 3000 DR Rotterdam, the Netherlands; Department of Child and Adolescent Psychiatry, University Medical Center Rotterdam, Erasmus MC, Sophia Children's Hospital, 3000 CB Rotterdam, the Netherlands., Franken IHA; Center for Substance Use and Addiction Research (CESAR), Department of Psychology, Education and Child Studies, Erasmus School of Social and Behavioral Science, Erasmus University Rotterdam, 3000 DR Rotterdam, the Netherlands., Muetzel RL; Department of Child and Adolescent Psychiatry, University Medical Center Rotterdam, Erasmus MC, Sophia Children's Hospital, 3000 CB Rotterdam, the Netherlands; Department of Radiology and Nuclear Medicine, Erasmus MC University Medical Center, the Netherlands., Cousijn J; Center for Substance Use and Addiction Research (CESAR), Department of Psychology, Education and Child Studies, Erasmus School of Social and Behavioral Science, Erasmus University Rotterdam, 3000 DR Rotterdam, the Netherlands., El Marroun H; Center for Substance Use and Addiction Research (CESAR), Department of Psychology, Education and Child Studies, Erasmus School of Social and Behavioral Science, Erasmus University Rotterdam, 3000 DR Rotterdam, the Netherlands; Department of Child and Adolescent Psychiatry, University Medical Center Rotterdam, Erasmus MC, Sophia Children's Hospital, 3000 CB Rotterdam, the Netherlands. Electronic address: h.marrounel@erasmusmc.nl.
Jazyk: angličtina
Zdroj: Biological psychology [Biol Psychol] 2024 Oct; Vol. 192, pp. 108859. Date of Electronic Publication: 2024 Sep 02.
DOI: 10.1016/j.biopsycho.2024.108859
Abstrakt: A prominent challenge in understanding neural consequences of substance use involves disentangling predispositional risk factors from resulting consequences of substance use. Existing literature has identified pre-existing brain variations as vulnerability markers for substance use throughout adolescence. As early initiation of use is an important predictor for later substance use problems, we examined whether pre-existing brain variations are associated with early initiation of use. In the Generation R Study, a prospective population-based cohort, brain morphology (gray matter volume, cortical thickness and surface area) was assessed at ages 10 and 14 using neuroimaging. In the second wave, participants reported on alcohol and tobacco use initiation. From a base study population (N = 3019), we examined the longitudinal (N = 2218) and cross-sectional (N = 1817) association between brain morphology of frontolimbic regions of interest known to be associated with substance use risk, and very early (age < 13) alcohol/tobacco use initiation. Additionally, longitudinal and cross-sectional associations were examined with a brain surface-based approach. Models were adjusted for age at neuroimaging, sex and relevant sociodemographic factors. No associations were found between brain morphology (ages 10 and 14) and early alcohol/tobacco use initiation (<13 years). Sex-specific analyses suggested a cross-sectional association between smaller brain volume and early initiated tobacco use in girls. Our findings are important for interpreting studies examining neural consequences of substance use in the general population. Future longitudinal studies are needed to specify whether these findings can be extended to initiation and continuation of alcohol/tobacco use in later stages of adolescence.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024. Published by Elsevier B.V.)
Databáze: MEDLINE
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