Automatic characterization of capillary flow profile of liquid samples on μTADs based on capacitance measurement.

Autor: Zhou J; Department of Electrical Engineering, Shantou University, 243 Daxue Road, Shantou, 515063, Guangdong, China., Li H; Department of Electrical Engineering, Shantou University, 243 Daxue Road, Shantou, 515063, Guangdong, China., Li X; Department of Biomedical Engineering, Shantou University, 243 Daxue Road, Shantou, 515063, Guangdong, China., Liang X; Department of Biomedical Engineering, Shantou University, 243 Daxue Road, Shantou, 515063, Guangdong, China., Feng Z; Department of Biomedical Engineering, Shantou University, 243 Daxue Road, Shantou, 515063, Guangdong, China., He Q; Department of Electrical Engineering, Shantou University, 243 Daxue Road, Shantou, 515063, Guangdong, China., Zhang M; Department of Electrical Engineering, Shantou University, 243 Daxue Road, Shantou, 515063, Guangdong, China., Chen X; Department of Biomedical Engineering, Shantou University, 243 Daxue Road, Shantou, 515063, Guangdong, China., Chen H; Department of Biomedical Engineering, Shantou University, 243 Daxue Road, Shantou, 515063, Guangdong, China., Zhang H; Guangdong University Research Findings Commercialization Center, Foshan, 528253, Guangdong, China., Guo W; Department of Biomedical Engineering, Shantou University, 243 Daxue Road, Shantou, 515063, Guangdong, China. Electronic address: guoweijin@stu.edu.cn.
Jazyk: angličtina
Zdroj: Journal of chromatography. A [J Chromatogr A] 2024 Oct 25; Vol. 1735, pp. 465328. Date of Electronic Publication: 2024 Aug 31.
DOI: 10.1016/j.chroma.2024.465328
Abstrakt: Capillary flow profile of liquid samples in porous media is closely related to the important properties of liquid samples, including the viscosity and the surface energy. Therefore, capillary flow profile can be used as an index to differentiate liquid samples with different properties. Fast and automatic characterization of capillary flow profile of liquid samples is necessary. In this work, we develop a portable and economical capacitance acquisition system (CASY) to easily obtain the capillary flow profile of liquid samples on microfluidic thread-based analytical devices (μTADs) by measuring the capacitance during the capillary flow. At first, we validate the accuracy of this method by comparing with the traditional method by video analysis in obtaining the capillary flow profiles in μTADs of cotton threads or glass fiber threads. Then we use it to differentiate liquid samples with different viscosity (mixture of water and glycerol). In addition, capillary flow profile on μTADs with chemical valves (chitosan or sucrose) can also be obtained on this device. Lastly, we show the potential of this device in measurement of hematocrit (HCT) of whole blood samples. This device can be used to catalog liquid biological samples with different properties in point-of-care diagnostics in the near future.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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