A skin-interfaced microfluidic platform supports dynamic sweat biochemical analysis during human exercise.

Autor: Cho S; Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA.; Center for Bio-Integrated Electronics, Northwestern University, Evanston, IL 60208, USA., Shaban SM; School of Chemical Engineering, Sungkyunkwan University, Suwon, 16419, Republic of Korea.; Biomedical Institute for Convergence at SKKU (BICS), Sungkyunkwan University, Suwon, 16419, Republic of Korea.; Petrochemical Department, Egyptian Petroleum Research Institute, Cairo, 11727, Egypt., Song R; Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA.; Department of Chemical and Biological Engineering, Northwestern University, Evanston, IL 60208, USA., Zhang H; Departments of Civil and Environmental Engineering, Northwestern University, Evanston, IL 60208, USA., Yang D; Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA.; Precision Biology Research Center (PBRC), Sungkyunkwan University, Suwon, 16419, Republic of Korea., Kim MJ; School of Chemical Engineering, Sungkyunkwan University, Suwon, 16419, Republic of Korea.; Biomedical Institute for Convergence at SKKU (BICS), Sungkyunkwan University, Suwon, 16419, Republic of Korea., Xiong Y; Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA.; Departments of Material Science and Engineering, Northwestern University, Evanston, IL 60208, USA., Li X; Departments of Civil and Environmental Engineering, Northwestern University, Evanston, IL 60208, USA., Madsen K; Center for Bio-Integrated Electronics, Northwestern University, Evanston, IL 60208, USA.; Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA., Wapnick S; Department of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA., Zhang S; Department of Statistics, School of Computer, Data and Information Sciences, University of Wisconsin-Madison, Madison, WI 53706, USA., Chen Z; Departments of Material Science and Engineering, Northwestern University, Evanston, IL 60208, USA., Kim J; Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA.; Center for Bio-Integrated Electronics, Northwestern University, Evanston, IL 60208, USA.; School of Chemical Engineering, Sungkyunkwan University, Suwon, 16419, Republic of Korea., Guinto G; College of Science and Health, DePaul University, Chicago, IL 60614, USA., Li M; Department of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA., Lee M; Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA.; Shirley Ryan AbilityLab, Chicago, IL 60611, USA.; Department of Physical Medicine and Rehabilitation, Northwestern University, Chicago, IL 60611, USA., Nuxoll RF; Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA.; Departments of Material Science and Engineering, Northwestern University, Evanston, IL 60208, USA.; Department of Physics and Astronomy, Northwestern University, Evanston, IL 60208, USA., Shajari S; Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA.; Center for Bio-Integrated Electronics, Northwestern University, Evanston, IL 60208, USA., Wang J; Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA.; Center for Bio-Integrated Electronics, Northwestern University, Evanston, IL 60208, USA.; Departments of Material Science and Engineering, Northwestern University, Evanston, IL 60208, USA.; Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL 60637, USA., Son S; Department of Bionano Engineering, Center for Bionano Intelligence Education and Research, Hanyang University, Ansan, 15588, Republic of Korea., Shin J; School of Chemical Engineering, Sungkyunkwan University, Suwon, 16419, Republic of Korea.; Biomedical Institute for Convergence at SKKU (BICS), Sungkyunkwan University, Suwon, 16419, Republic of Korea., Aranyosi AJ; Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA.; Center for Bio-Integrated Electronics, Northwestern University, Evanston, IL 60208, USA.; Epicore Biosystems, Cambridge, MA 02139, USA., Wright DE; Epicore Biosystems, Cambridge, MA 02139, USA., Kim TI; School of Chemical Engineering, Sungkyunkwan University, Suwon, 16419, Republic of Korea.; Biomedical Institute for Convergence at SKKU (BICS), Sungkyunkwan University, Suwon, 16419, Republic of Korea., Ghaffari R; Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA.; Center for Bio-Integrated Electronics, Northwestern University, Evanston, IL 60208, USA.; Department of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA.; Epicore Biosystems, Cambridge, MA 02139, USA., Huang Y; Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA.; Departments of Civil and Environmental Engineering, Northwestern University, Evanston, IL 60208, USA.; Departments of Material Science and Engineering, Northwestern University, Evanston, IL 60208, USA.; Department of Mechanical Engineering, Northwestern University, Evanston, IL 60208, USA., Kim DH; School of Chemical Engineering, Sungkyunkwan University, Suwon, 16419, Republic of Korea.; Biomedical Institute for Convergence at SKKU (BICS), Sungkyunkwan University, Suwon, 16419, Republic of Korea., Rogers JA; Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA.; Center for Bio-Integrated Electronics, Northwestern University, Evanston, IL 60208, USA.; Departments of Material Science and Engineering, Northwestern University, Evanston, IL 60208, USA.; Department of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA.; Department of Neurological Surgery, Northwestern University, Evanston, IL 60208, USA.
Jazyk: angličtina
Zdroj: Science translational medicine [Sci Transl Med] 2024 Sep 04; Vol. 16 (763), pp. eado5366. Date of Electronic Publication: 2024 Sep 04.
DOI: 10.1126/scitranslmed.ado5366
Abstrakt: Blood lactate concentration is an established circulating biomarker for measuring muscle acidity and can be evaluated for monitoring endurance, training routines, or athletic performance. Sweat is an alternative biofluid that may serve similar purposes and offers the advantage of noninvasive collection and continuous monitoring. The relationship between blood lactate and dynamic sweat biochemistry for wearable engineering applications in physiological fitness remains poorly defined. Here, we developed a microfluidic wearable band with an integrated colorimetric timer and biochemical assays that temporally captures sweat and measures pH and lactate concentration. A colorimetric silver nanoplasmonic assay was used to measure the concentration of lactate, and dye-conjugated SiO 2 nanoparticle-agarose composite materials supported dynamic pH analysis. We evaluated these sweat biomarkers in relation to blood lactate in human participant studies during cycling exercise of varying intensity. Iontophoresis-generated sweat pH from regions of actively working muscles decreased with increasing heart rate during exercise and was negatively correlated with blood lactate concentration. In contrast, sweat pH from nonworking muscles did not correlate with blood lactate concentration. Changes in sweat pH and blood lactate were observed in participants who did not regularly exercise but not in individuals who regularly exercised, suggesting a relationship to physical fitness and supporting further development for noninvasive, biochemical fitness evaluations.
Databáze: MEDLINE