Association of biomarkers of endothelial function, coagulation activation and kidney injury with persistent albuminuria in sickle cell anaemia.

Autor: Elsherif L; Center for Sickle Cell Disease, University of Tennessee Health Science Center, Memphis, Tennessee, USA., Tang Y; Department of Biostatistics, University of North Carolina, Chapel Hill, North Carolina, USA., Patillo KL; Office of Clinical Trials, University of Tennessee Health Science Center, Memphis, Tennessee, USA., Wichlan D; Division of Hematology, University of North Carolina, Chapel Hill, North Carolina, USA., Ogu UO; Center for Sickle Cell Disease, University of Tennessee Health Science Center, Memphis, Tennessee, USA., Landes K; Division of Hematology, The Ohio State University, Columbus, Ohio, USA., McCune P; Office of Clinical Trials, University of Tennessee Health Science Center, Memphis, Tennessee, USA., Scott LC; College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, USA., Gulledge W; College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, USA., Woodland WH; College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, USA., Nelson M; Center for Sickle Cell Disease, University of Tennessee Health Science Center, Memphis, Tennessee, USA., Loehr LR; Division of General Medicine and Epidemiology, University of North Carolina, Chapel Hill, North Carolina, USA., Cronin RM; Department of Internal Medicine, The Ohio State University, Columbus, Ohio, USA., Desai PC; Levine Cancer Institute - Atrium Health, Wake Forest School of Medicine, Charlotte, North Carolina, USA., Zhou LY; Department of Biostatistics and Health Data Science, Indiana University School of Medicine, Indianapolis, Indiana, USA., Pollock DM; Division of Nephrology, University of Alabama at Birmingham, Birmingham, Alabama, USA., Zou F; Department of Biostatistics, University of North Carolina, Chapel Hill, North Carolina, USA., Cai J; Department of Biostatistics, University of North Carolina, Chapel Hill, North Carolina, USA., Derebail VK; Division of Nephrology and Hypertension, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Ataga KI; Center for Sickle Cell Disease, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
Jazyk: angličtina
Zdroj: British journal of haematology [Br J Haematol] 2024 Nov; Vol. 205 (5), pp. 1963-1973. Date of Electronic Publication: 2024 Sep 03.
DOI: 10.1111/bjh.19743
Abstrakt: Persistent albuminuria (PA) is common in sickle cell anaemia (SCA). With the association of chronic kidney disease (CKD) with increased mortality, biomarkers that predict its development or progression are needed. We evaluated the association of select biomarkers with PA in adults with SCA using Kruskal-Wallis rank-sum test and logistic regression models, with adjustment for multiple testing. Of 280 subjects, 100 (35.7%) had PA. Median plasma levels of soluble vascular cell adhesion molecule-1 (VCAM-1) (1176.3 vs. 953.4 ng/mL, false discovery rate [FDR] q-value <0.003), thrombin-antithrombin complex (5.5 vs. 4.7 ng/mL, FDR q-value = 0.04), and urinary angiotensinogen (AGT) (12.2 vs. 5.3 ng/mg, FDR q-value <0.003), urinary nephrin (30.6 vs. 27.2 ng/mg, FDR q-value = 0.04), and urinary kidney injury molecule-1 (KIM-1) (0.8 vs. 0.5 ng/mg, FDR q-value <0.003), normalized to urine creatinine, were significantly higher in subjects with PA. In multivariable analysis, only urinary AGT (odds ratio = 1.058, FDR q-value <0.0001) remained a significant predictor of PA. In addition, soluble VCAM-1 (FDR q-value <0.0001), D-dimer (FDR q-value <0.0001), urinary AGT (FDR q-value <0.0001), KIM-1 (FDR q-value <0.0001), and nephrin (FDR q-value <0.0001) were significantly associated with urine albumin-creatinine ratio in multivariable analyses. Longitudinal studies to evaluate the predictive capacity of biomarkers for the development and progression of CKD in SCA are warranted.
(© 2024 British Society for Haematology and John Wiley & Sons Ltd.)
Databáze: MEDLINE
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