Chromosomal instability: a key driver in glioma pathogenesis and progression.

Autor: Mazzoleni A; Barts and the London School of Medicine and Dentistry, London, UK., Awuah WA; Sumy State University, Sumy, Ukraine. andyvans36@yahoo.com., Sanker V; Department Of Neurosurgery, Trivandrum Medical College, Trivandrum, India., Bharadwaj HR; Faculty of Biology Medicine and Health, The University of Manchester, Manchester, UK., Aderinto N; Internal Medicine Department, LAUTECH Teaching Hospital, Ogbomoso, Nigeria., Tan JK; Faculty of Medicine, University of St Andrews, St. Andrews, Scotland, UK., Huang HYR; Royal College of Surgeons in Ireland, University of Medicine and Health Sciences, Dublin, Ireland., Poornaselvan J; School of Medicine, University College Dublin, Dublin, Ireland., Shah MH; School of Medicine, Queen's University Belfast, Belfast, UK., Atallah O; Department of Neurosurgery, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625, Hannover, Germany., Tawfik A; Faculty of Biotechnology, October University for Modern Sciences and Arts (MSA), Giza, Egypt., Elmanzalawi MEAE; Graduate University for Advanced Studies, SOKENDAI, Kanagawa, Japan., Ghozlan SH; Arab Academy for Science, Technology & Maritime Transport, Alexandria, Egypt., Abdul-Rahman T; Sumy State University, Sumy, Ukraine., Moyondafoluwa JA; Faculty of Clinical Sciences, Department of Medicine and Surgery, Ile-Ife, Osun State, Nigeria., Alexiou A; University Centre for Research & Development, Chandigarh University, Chandigarh-Ludhiana Highway, Mohali, Punjab, India.; Funogen, Department of Research & Development, Athens, Greece.; Department of Research & Development, AFNP Med, 1030, Vienna, Austria.; Department of Science and Engineering, Novel Global Community Educational Foundation, Hebersham, NSW, 2770, Australia., Papadakis M; Department of Surgery II, University Hospital Witten-Herdecke, University of Witten-Herdecke, Heusnerstrasse 40, 42283, Wuppertal, Germany. drmariospapadakis@gmail.com.
Jazyk: angličtina
Zdroj: European journal of medical research [Eur J Med Res] 2024 Sep 04; Vol. 29 (1), pp. 451. Date of Electronic Publication: 2024 Sep 04.
DOI: 10.1186/s40001-024-02043-8
Abstrakt: Chromosomal instability (CIN) is a pivotal factor in gliomas, contributing to their complexity, progression, and therapeutic challenges. CIN, characterized by frequent genomic alterations during mitosis, leads to genetic abnormalities and impacts cellular functions. This instability results from various factors, including replication errors and toxic compounds. While CIN's role is well documented in cancers like ovarian cancer, its implications for gliomas are increasingly recognized. CIN influences glioma progression by affecting key oncological pathways, such as tumor suppressor genes (e.g., TP53), oncogenes (e.g., EGFR), and DNA repair mechanisms. It drives tumor evolution, promotes inflammatory signaling, and affects immune interactions, potentially leading to poor clinical outcomes and treatment resistance. This review examines CIN's impact on gliomas through a narrative approach, analyzing data from PubMed/Medline, EMBASE, the Cochrane Library, and Scopus. It highlights CIN's role across glioma subtypes, from adult glioblastomas and astrocytomas to pediatric oligodendrogliomas and astrocytomas. Key findings include CIN's effect on tumor heterogeneity and its potential as a biomarker for early detection and monitoring. Emerging therapies targeting CIN, such as those modulating tumor mutation burden and DNA damage response pathways, show promise but face challenges. The review underscores the need for integrated therapeutic strategies and improved bioinformatics tools like CINdex to advance understanding and treatment of gliomas. Future research should focus on combining CIN-targeted therapies with immune modulation and personalized medicine to enhance patient outcomes.
(© 2024. The Author(s).)
Databáze: MEDLINE
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