Wychimicins E and F from a rare actinomycete of the genus Cryptosporangium.

Autor: Triningsih DW; Biotechnology Research Center and Department of Biotechnology, Toyama Prefectural University 5180 Kurokawa, Imizu, Toyama, 939-0398, Japan., Yoshizaki N; Biotechnology Research Center and Department of Biotechnology, Toyama Prefectural University 5180 Kurokawa, Imizu, Toyama, 939-0398, Japan., Igarashi Y; Biotechnology Research Center and Department of Biotechnology, Toyama Prefectural University 5180 Kurokawa, Imizu, Toyama, 939-0398, Japan. yas@pu-toyama.ac.jp.
Jazyk: angličtina
Zdroj: The Journal of antibiotics [J Antibiot (Tokyo)] 2024 Dec; Vol. 77 (12), pp. 847-851. Date of Electronic Publication: 2024 Sep 03.
DOI: 10.1038/s41429-024-00770-y
Abstrakt: Two new spirotetronate class compounds designated wychimicins E (1) and F (2) were isolated from the culture extract of an actinomycete Cryptosporangium sp. RD061707. Their structures were determined through extensive NMR analysis in comparison with wychimicin C. Both compounds lack one hydroxy group in the decalin moiety, and the relative configuration of the remaining hydroxy group was assigned by NMR analysis of triacetylwychimicin E (3). Compounds 1 and 2 showed potent antimicrobial activity against Kocuria rhizophila and Staphylococcus aureus. These compounds were also modestly cytotoxic against P388 murine leukemia cells.
Competing Interests: Compliance with ethical standards. Conflict of interest: The authors declare no competing interests.
(© 2024. The Author(s), under exclusive licence to the Japan Antibiotics Research Association.)
Databáze: MEDLINE
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