The neurodegenerative hypothesis of depression and the influence of antidepressant medications.

Autor: Hall S; School of Pharmacy and Medical Sciences, Griffith University Gold Coast Campus, Southport, 4222, Australia. Electronic address: s.hall@griffith.edu.au., Parr BA; School of Pharmacy and Medical Sciences, Griffith University Gold Coast Campus, Southport, 4222, Australia., Hussey S; School of Pharmacy and Medical Sciences, Griffith University Gold Coast Campus, Southport, 4222, Australia., Anoopkumar-Dukie S; School of Pharmacy and Medical Sciences, Griffith University Gold Coast Campus, Southport, 4222, Australia., Arora D; School of Pharmacy and Medical Sciences, Griffith University Gold Coast Campus, Southport, 4222, Australia., Grant GD; School of Pharmacy and Medical Sciences, Griffith University Gold Coast Campus, Southport, 4222, Australia.
Jazyk: angličtina
Zdroj: European journal of pharmacology [Eur J Pharmacol] 2024 Nov 15; Vol. 983, pp. 176967. Date of Electronic Publication: 2024 Sep 01.
DOI: 10.1016/j.ejphar.2024.176967
Abstrakt: Depression is a complex neurological disease that holds many theories on its aetiology and pathophysiology. The monoamine strategy of treating depression with medications to increase levels of monoamines in the (extra)synapse, primarily through the inhibition of monoamine transporters, does not always work, as seen in patients that lack a response to multiple anti-depressant exposures, as well as a lack of depressive symptoms in healthy volunteers exposed to monoamine reduction. Depression is increasingly being understood not as a single condition, but as a complex interplay of adaptations in various systems, including inflammatory responses and neurotransmission pathways in the brain. This understanding has led to the development of the neurodegenerative hypothesis of depression. This hypothesis, which is gaining widespread acceptance posits that both oxidative stress and inflammation play significant roles in the pathophysiology of depression. This article is a review of the literature focused on neuroinflammation in depression, as well as summarised studies of anti-inflammatory and antioxidant effects of antidepressants.
Competing Interests: Declaration of competing interest We confirm that the paper has been seen and reviewed by co-authors, approved the submission to the journal. We confirm that there are no conflicts of interest in this paper.
(Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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