Medical, Environmental, and Social Determinants Associated With Periocular Cutaneous Malignancies in the United States Using the All of Us National Database.

Autor:	Radgoudarzi N; Division of Ophthalmology Informatics and Data Science, Viterbi Family Department of Ophthalmology and Shiley Eye Institute, University of California San Diego, La Jolla, USA., Dallalzadeh L; Division of Oculofacial Plastic and Orbital Surgery, Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, USA., Saseendrakumar BR; Division of Ophthalmology Informatics and Data Science, Viterbi Family Department of Ophthalmology and Shiley Eye Institute, University of California San Diego, La Jolla, USA., Guo J; Health Department of Biomedical Informatics, University of California San Diego, La Jolla, USA., Halfpenny W; Division of Ophthalmology Informatics and Data Science, Viterbi Family Department of Ophthalmology and Shiley Eye Institute, University of California San Diego, La Jolla, USA., Kikkawa DO; Division of Oculofacial Plastic and Reconstructive Surgery, Viterbi Family Department of Ophthalmology and Shiley Eye Institute, University of California San Diego, La Jolla, USA., Baxter S; Division of Ophthalmology Informatics and Data Science, Viterbi Family Department of Ophthalmology and Shiley Eye Institute, University of California San Diego, La Jolla, USA.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2024 Jul 31; Vol. 16 (7), pp. e65831. Date of Electronic Publication: 2024 Jul 31 (Print Publication: 2024).
DOI:	10.7759/cureus.65831
Abstrakt:	Objective: To identify common factors associated with periocular cutaneous malignancies using the National Institutes of Health (NIH) All of Us database. Methodology: In this case-control study, we extracted electronic health records and sociodemographic data for 385 cases of periocular cutaneous malignancies from the All of Us nationwide database. Controls ( N = 1540) were matched to the demographic characteristics of the 2020 United States Census. Bivariate analyses and multivariable logistic regression determined variables significantly associated with increased odds of periocular cutaneous malignancies. We analyzed medical, environmental, and social determinants to evaluate which factors were associated with increased odds of periocular cutaneous malignancies. Results: Among the cases, the mean (standard deviation) age was 66.8 (11.2) years at the time of diagnosis. The majority were male (207, 54%) and white (361, 94%). Periocular cutaneous malignancy was significantly more likely among individuals with high sun exposure (odds ratio [OR] 14.79, 95% confidence interval [CI] 3.35-85.73, P  = 0.001), those identifying as white race (OR 3.88, 95% CI 1.06-25.33, P  = 0.079), and those with higher socioeconomic status, including higher annual income (OR 1.35, 95% CI 1.25-1.46, P  < 0.001). Conclusions: This study demonstrates similar risk factors for periocular cutaneous malignancies, echoing prior research that showed increased associations with lighter-pigmented skin and higher socioeconomic status. It also sheds light on the positive impact of physician surveillance and health utilization factors in the early detection and treatment of these malignancies, aspects less explored in prior analyses. Competing Interests: Human subjects: Consent was obtained or waived by all participants in this study. The University of California Institutional Review Board issued approval N/A. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: Author Niloofar Radgoudarzi is a recipient of the Research to Prevent Blindness Medical Student Eye Research Fellowship (New York, NY). This study was supported by NIH grants DP5OD029610, P30EY022589, and an unrestricted departmental grant from Research to Prevent Blindness, UC San Diego. The All of Us Research Program is supported (or funded) by grants through the National Institutes of Health, Office of the Director: Regional Medical Centers: 1 OT2 OD026549; 1 OT2 OD026554; 1 OT2 OD026557; 1 OT2 OD026556; 1 OT2 OD026550; 1 OT2 OD 026552; 1 OT2 OD026553; 1 OT2 OD026548; 1 OT2 OD026551; 1 OT2 OD026555; IAA #: AOD 16037; Federally Qualified Health Centers: HHSN 263201600085U; Data and Research Center: 5 U2C OD023196; Biobank: 1 U24 OD023121; The Participant Center: U24 OD023176; Participant Technology Systems Center: 1 U24 OD023163; Communications and Engagement: 3 OT2 OD023205; 3 OT2 OD023206; and Community Partners: 1 OT2 OD025277; 3 OT2 OD025315; 1 OT2 OD025337; 1 OT2 OD025276. In addition to the funded partners, the All of Us Research Program would not be possible without the contributions made by its participants. Financial relationships: Don O. Kikkawa declare(s) personal fees from Horizon Therapeutics. Ended. Don O. Kikkawa declare(s) royalties from Elsevier. Sally L. Baxter declare(s) personal fees from Topcon. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. (Copyright © 2024, Radgoudarzi et al.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu