The efficacy of diazepam administration during embryo transfer: a retrospective multicenter cohort study on reproductive outcomes.

Autor: Brandão P; IVIRMA Global Research Alliance, Ginemed Porto, Avenida da Boavista 1243, 4100-130, Porto, Portugal. pbrandao@ginemed.pt., Rafael F; IVIRMA Global Research Alliance, Ginemed Porto, Avenida da Boavista 1243, 4100-130, Porto, Portugal., Saleh M; IVIRMA Global Research Alliance, Ginemed Porto, Avenida da Boavista 1243, 4100-130, Porto, Portugal., Sánchez F; IVIRMA Global Research Alliance, Ginemed Porto, Avenida da Boavista 1243, 4100-130, Porto, Portugal.; IVIRMA Global Research Alliance, Ginemed Sevilla, Calle Farmaceutico Murillo Herrera, 3, 41010, Seville, Spain.
Jazyk: angličtina
Zdroj: Journal of assisted reproduction and genetics [J Assist Reprod Genet] 2024 Sep; Vol. 41 (9), pp. 2379-2383. Date of Electronic Publication: 2024 Aug 31.
DOI: 10.1007/s10815-024-03206-6
Abstrakt: Purpose: This retrospective multicenter cohort study aimed to investigate the impact of diazepam administration during embryo transfer on reproductive outcomes, focusing primarily on the live birth rate. Secondary outcomes included the positive beta-hCG rate, clinical pregnancy rate, miscarriage rate, ectopic pregnancy rate, and preterm birth rate.
Methods: Data from 5607 embryo transfers, encompassing 465 cases with diazepam administration, were retrospectively analyzed. The study included single blastocyst transfers from 12 clinics in Portugal and Spain between January 2015 and December 2022.
Results: Comparison of reproductive outcomes between patients receiving diazepam and those who did not showed no statistically significant differences. Positive beta-hCG rates (60.8% non-diazepam vs. 60.4% diazepam, p = 0.92, adjusted p = 0.32) and clinical pregnancy rates (45.6% non-diazepam vs. 46.2% diazepam, p = 0.81, adjusted p = 0.11) were comparable. Miscarriage rates (11.0% diazepam vs. 9.3% non-diazepam, p = 0.25, adjusted p = 0.26) and ectopic pregnancy rates (0.9% diazepam vs. 0.1% non-diazepam, p = 0.1, adjusted p = 0.20) were similar. Live birth rates (36.3% non-diazepam vs. 35.3% diazepam, p = 0.69, adjusted p = 0.82) and prematurity rates (0.3% non-diazepam vs. 0% diazepam, p > 0.99, adjusted p = 0.99) also exhibited no statistically significant differences.
Conclusions: Based on the results, diazepam administration during embryo transfer did not show a discernible impact on reproductive outcomes, including live birth rates, suggesting its limited effectiveness in enhancing success.
(© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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