Large-scale HEV genotype 3 outbreak on New Caledonia Island.

Autor:	Abravanel F; Toulouse University Hospital, Hôpital Purpan, Place du Dr Baylac, Laboratoire de Virologie, National Reference Centre for Hepatitis E, Toulouse, France.; Inserm UMR 1291 - CNRS UMR5051 - Université Toulouse III, Toulouse, France Toulouse University Hospital, Hôpital Purpan, Place du Dr Baylac, Toulouse., Vignon C; Toulouse University Hospital, Hopital Rangueil Service d'hépatologie - 1 Avenue du Pr J. Poulhes- Université Paul Sabatier III, Toulouse France, Nouvelle-Calédonie., Mercier A; Territorial Hospital Centre Gaston-Bourret, Service de Transfusion Sanguine 110, boulevard Joseph-Wamytan, Nouméa Cedex., Gaumery JB; Direction des Affaires Sanitaire et Sociale, 7 avenue Paul DOUMER, BP M2, NOUMÉA Cedex, Nouvelle-Calédonie., Biron A; Territorial Hospital Centre Gaston-Bourret, Service de Transfusion Sanguine 110, boulevard Joseph-Wamytan, Nouméa Cedex., Filisetti C; Direction des Affaires Sanitaire et Sociale, 7 avenue Paul DOUMER, BP M2, NOUMÉA Cedex, Nouvelle-Calédonie., Goujart MA; Territorial Hospital Centre Gaston-Bourret, Service de Transfusion Sanguine 110, boulevard Joseph-Wamytan, Nouméa Cedex., Colot J; Territorial Hospital Centre Gaston-Bourret, Service de Transfusion Sanguine 110, boulevard Joseph-Wamytan, Nouméa Cedex., Chamillard X; Territorial Hospital Centre Gaston-Bourret, Service de Transfusion Sanguine 110, boulevard Joseph-Wamytan - BP J5, Nouméa Cedex., Demortier J; Territorial Hospital Centre Gaston-Bourret, Service de Transfusion Sanguine 110, boulevard Joseph-Wamytan - BP J5, Nouméa Cedex., Raz M; Territorial Hospital Centre Gaston-Bourret, Service de Transfusion Sanguine 110, boulevard Joseph-Wamytan - BP J5, Nouméa Cedex., Boutet C; Direction des Affaires Sanitaire et Sociale, 7 avenue Paul DOUMER, BP M2, NOUMÉA Cedex, Nouvelle-Calédonie., Dupont L; Direction des Affaires Sanitaire et Sociale, 7 avenue Paul DOUMER, BP M2, NOUMÉA Cedex, Nouvelle-Calédonie., Duval S; Direction des affaires vétérinaires, alimentaires et rurales 2 Rue Felix Russeil, Nouméa, Nouvelle-Calédonie., Castric C; Direction des affaires vétérinaires, alimentaires et rurales 2 Rue Felix Russeil, Nouméa, Nouvelle-Calédonie., Desoutter D; Direction des affaires vétérinaires, alimentaires et rurales 2 Rue Felix Russeil, Nouméa, Nouvelle-Calédonie., Desoutter A; Direction des affaires vétérinaires, alimentaires et rurales 2 Rue Felix Russeil, Nouméa, Nouvelle-Calédonie., Verge M; Direction des affaires vétérinaires, alimentaires et rurales 2 Rue Felix Russeil, Nouméa, Nouvelle-Calédonie., De Smet C; Toulouse University Hospital, Hôpital Purpan, Place du Dr Baylac, Laboratoire de Virologie, National Reference Centre for Hepatitis E, Toulouse, France., Demmou S; Toulouse University Hospital, Hôpital Purpan, Place du Dr Baylac, Laboratoire de Virologie, National Reference Centre for Hepatitis E, Toulouse, France., Lhomme S; Toulouse University Hospital, Hôpital Purpan, Place du Dr Baylac, Laboratoire de Virologie, National Reference Centre for Hepatitis E, Toulouse, France.; Inserm UMR 1291 - CNRS UMR5051 - Université Toulouse III, Toulouse, France Toulouse University Hospital, Hôpital Purpan, Place du Dr Baylac, Toulouse., Gourinat AC; Direction des Affaires Sanitaire et Sociale, 7 avenue Paul DOUMER, BP M2, NOUMÉA Cedex, Nouvelle-Calédonie., Nicot F; Toulouse University Hospital, Hôpital Purpan, Place du Dr Baylac, Laboratoire de Virologie, National Reference Centre for Hepatitis E, Toulouse, France., Izopet J; Toulouse University Hospital, Hôpital Purpan, Place du Dr Baylac, Laboratoire de Virologie, National Reference Centre for Hepatitis E, Toulouse, France.; Inserm UMR 1291 - CNRS UMR5051 - Université Toulouse III, Toulouse, France Toulouse University Hospital, Hôpital Purpan, Place du Dr Baylac, Toulouse.
Jazyk:	angličtina
Zdroj:	Hepatology (Baltimore, Md.) [Hepatology] 2024 Aug 30. Date of Electronic Publication: 2024 Aug 30.
DOI:	10.1097/HEP.0000000000001081
Abstrakt:	Background and Aims: Several symptomatic cases of HEV infections were reported to the New Caledonia Island Public Health Service between August and December 2023. This prompted epidemiological and virological investigations to identify the source of infection. Approach and Results: HEV RNA was assessed in symptomatic patients, various food items, and pig farms on the Island. HEV strains were characterized by sequencing. A seroprevalence study was also conducted on asymptomatic blood donors before and after the outbreak. One hundred twenty-seven symptomatic cases were reported. Hospitalization was required for 29/127 patients (22.8%). Hospitalized patients presented more frequently with comorbidities, including liver and cardiovascular diseases (80.7% vs. 27%, p < 0.01), and 3 persons died (2.3%). Among the 100 HEV RNA-positive samples received at the French National Reference Centre for HEV, viral sequencing was possible for 76 samples. All strains were identified as HEV genotype 3, and 74/76 strains were grouped together (nucleotide identity: 98%-100%). Full-length sequencing indicated a new HEV-3 subtype within HEV-3 subclade abk. Only genotype 3f strains were detected on the Island's pig farms. No food items tested positive for HEV RNA. The seroprevalence of HEV IgG and IgM in blood donors was 9.2% (9/98) and 0%, respectively, in 2020, rising to 17.3% (17/98) and 2% (2/98) in 2024. Conclusions: Although all previous large-scale epidemics in Asia and Africa were associated with HEV-1 or 2, the New Caledonia outbreak was linked to HEV-3. A high number of symptomatic cases were admitted to the hospital, with a case-fatality rate of 2.3%. (Copyright © 2024 American Association for the Study of Liver Diseases.)
Databáze:	MEDLINE
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