Photobiomodulation use in ophthalmology - an overview of translational research from bench to bedside.
| Autor: | Valter K; Clear Vision Laboratory, John Curtin School of Medical Research, Eccles Institute of Neuroscience, Canberra, ACT, Australia.; School of Medicine and Psychology, Australian National University, Canberra, ACT, Australia., Tedford SE; LumiThera, Inc., Poulsbo, WA, United States., Eells JT; College of Health Professions and Sciences, University of Wisconsin-Milwaukee, Milwaukee, WI, United States., Tedford CE; LumiThera, Inc., Poulsbo, WA, United States. |
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| Jazyk: | angličtina |
| Zdroj: | Frontiers in ophthalmology [Front Ophthalmol (Lausanne)] 2024 Aug 15; Vol. 4, pp. 1388602. Date of Electronic Publication: 2024 Aug 15 (Print Publication: 2024). |
| DOI: | 10.3389/fopht.2024.1388602 |
| Abstrakt: | Photobiomodulation (PBM) refers to the process in which wavelengths of light are absorbed by intracellular photoacceptors, resulting in the activation of signaling pathways that culminate in biological changes within the cell. PBM is the result of low-intensity light-induced reactions in the cell in contrast to thermal photoablation produced by high-intensity lasers. PBM has been effectively used in the clinic to enhance wound healing and mitigate pain and inflammation in musculoskeletal conditions, sports injury, and dental applications for many decades. In the past 20 years, experimental evidence has shown the benefit of PBM in increasing numbers of retinal and ophthalmic conditions. More recently, preclinical findings in ocular models have been translated to the clinic with promising results. This review discusses the preclinical and clinical evidence of the effects of PBM in ophthalmology and provides recommendations of the clinical use of PBM in the management of ocular conditions. Competing Interests: Authors ST and CT were employed by LumiThera, Inc. JE disclosures include MultiRadiance Medical and LumiThera, Inc. The remaining author declares that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2024 Valter, Tedford, Eells and Tedford.) |
| Databáze: | MEDLINE |
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