| Autor: |
Damian-Buda AC; Pharmacology, Toxicology and Clinical Pharmacology Laboratory, 'Iuliu Hațieganu' University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania., Matei DM; Department of Internal Medicine, 'Iuliu Hațieganu' University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.; Regional Institute of Gastroenterology and Hepatology, 400162 Cluj-Napoca, Romania., Ciobanu L; Department of Internal Medicine, 'Iuliu Hațieganu' University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.; Regional Institute of Gastroenterology and Hepatology, 400162 Cluj-Napoca, Romania., Damian-Buda DZ; Regional Institute of Gastroenterology and Hepatology, 400162 Cluj-Napoca, Romania., Pop RM; Pharmacology, Toxicology and Clinical Pharmacology, Department of Morphofunctional Sciences, 'Iuliu Haţieganu' University of Medicine and Pharmacy, Victor Babeș, No 8, 400012 Cluj-Napoca, Romania., Buzoianu AD; Pharmacology, Toxicology and Clinical Pharmacology, Department of Morphofunctional Sciences, 'Iuliu Haţieganu' University of Medicine and Pharmacy, Victor Babeș, No 8, 400012 Cluj-Napoca, Romania., Bocsan IC; Pharmacology, Toxicology and Clinical Pharmacology, Department of Morphofunctional Sciences, 'Iuliu Haţieganu' University of Medicine and Pharmacy, Victor Babeș, No 8, 400012 Cluj-Napoca, Romania. |
| Abstrakt: |
Nesfatin-1, deriving from a precursor protein, NUCB2, is a newly discovered molecule with anti-apoptotic, anti-inflammatory, antioxidant, and anorexigenic effects. It was initially identified in the central nervous system (CNS) and received increasing interest due to its energy-regulating properties. However, research showed that nesfatin-1 is also expressed in peripheral tissues, including the digestive system. The aim of this review is to give a résumé of the present state of knowledge regarding its structure, immunolocalization, and potential implications in diseases with inflammatory components. The main objective was to focus on its clinical importance as a diagnostic biomarker and potential therapeutic molecule in a variety of disorders, among which digestive disorders were of particular interest. Previous studies have shown that nesfatin-1 regulates the balance between pro- and antioxidant agents, which makes nesfatin-1 a promising therapeutic agent. Further in-depth research regarding the underlying mechanisms of action is needed for a better understanding of its effects. |
