Serum Adiponectin Levels Increase in Acute Ischemic Stroke and Correlate with Patients' Outcomes: A Pilot Study.

Autor:	Zaharia AL; Faculty of Medicine and Pharmacy, 'Dunărea de Jos' University of Galaţi, 800216 Galaţi, Romania.; 'St. Apostle Andrei' Clinical Emergency County Hospital Galaţi, 800578 Galaţi, Romania., Oprea VD; Faculty of Medicine and Pharmacy, 'Dunărea de Jos' University of Galaţi, 800216 Galaţi, Romania.; 'St. Apostle Andrei' Clinical Emergency County Hospital Galaţi, 800578 Galaţi, Romania., Coadă CA; Faculty of Medicine, 'Iuliu Haţieganu' University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania., Tănase CE; Faculty of Medicine and Pharmacy, 'Dunărea de Jos' University of Galaţi, 800216 Galaţi, Romania., Ionescu AM; Faculty of Medicine, Ovidius University of Constanța, 900470 Constanța, Romania., Chirila SI; Faculty of Medicine, Ovidius University of Constanța, 900470 Constanța, Romania., Mihailov R; Faculty of Medicine and Pharmacy, 'Dunărea de Jos' University of Galaţi, 800216 Galaţi, Romania.; 'St. Apostle Andrei' Clinical Emergency County Hospital Galaţi, 800578 Galaţi, Romania., Tutunaru D; Faculty of Medicine and Pharmacy, 'Dunărea de Jos' University of Galaţi, 800216 Galaţi, Romania.; 'St. Apostle Andrei' Clinical Emergency County Hospital Galaţi, 800578 Galaţi, Romania., Lungu M; Faculty of Medicine and Pharmacy, 'Dunărea de Jos' University of Galaţi, 800216 Galaţi, Romania.; 'St. Apostle Andrei' Clinical Emergency County Hospital Galaţi, 800578 Galaţi, Romania.
Jazyk:	angličtina
Zdroj:	Biomedicines [Biomedicines] 2024 Aug 12; Vol. 12 (8). Date of Electronic Publication: 2024 Aug 12.
DOI:	10.3390/biomedicines12081828
Abstrakt:	Stroke is a leading cause of death and severe disability worldwide. Rapid diagnosis is critical to ensure the timely administration of medical treatment. Given that in some cases CT scans fail to show the classic clinical signs of stroke, we aimed to evaluate the diagnostic capacity of adiponectin levels and their association with the clinical parameters of patients with acute ischemic stroke (AIS). Adiponectin was measured within 24 h (T1) and 48 h (T2) of AIS onset in 70 patients. A total of 68 control cases were included in the study. Adiponectin levels were significantly higher in the AIS patients than in the controls (16.64 (3.79; 16.69) vs. 3.78 (3.79; 16.69); p < 0.001), with an accuracy of 0.98 (AUC = 0.99). Lower levels were seen in males and in AIS patients with obesity. Higher levels of adiponectin at T1 were associated with a moderate/severe NIHSS score at patient discharge. Moreover, higher levels of borderline significance were seen in patients who died within 12 months of their AIS episode ( p = 0.054). Adiponectin may be a useful biomarker for the identification of AIS patients who do not present classic CT signs and could be used to stratify severe cases. Further studies are needed to validate these results.
Databáze:	MEDLINE
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