| Autor: |
Tam SY; School of Medical and Health Sciences, Tung Wah College, Hong Kong., Tang FH; School of Medical and Health Sciences, Tung Wah College, Hong Kong., Chan MY; School of Medical and Health Sciences, Tung Wah College, Hong Kong., Lai HC; School of Medical and Health Sciences, Tung Wah College, Hong Kong., Cheung S; School of Medical and Health Sciences, Tung Wah College, Hong Kong. |
| Jazyk: |
angličtina |
| Zdroj: |
Biomedicines [Biomedicines] 2024 Jul 24; Vol. 12 (8). Date of Electronic Publication: 2024 Jul 24. |
| DOI: |
10.3390/biomedicines12081646 |
| Abstrakt: |
(1) Background: head and neck squamous cell carcinoma (HNSCC) is a common cancer whose prognosis is affected by its heterogeneous nature. We aim to predict 5-year overall survival in HNSCC radiotherapy (RT) patients by integrating radiomic and clinical information in machine-learning models; (2) Methods: HNSCC radiotherapy planning computed tomography (CT) images with RT structures were obtained from The Cancer Imaging Archive. Radiomic features and clinical data were independently analyzed by five machine-learning algorithms. The results were enhanced through a voted ensembled approach. Subsequently, a probability-weighted enhanced model (PWEM) was generated by incorporating both models; (3) Results: a total of 299 cases were included in the analysis. By receiver operating characteristic (ROC) curve analysis, PWEM achieved an area under the curve (AUC) of 0.86, which outperformed both radiomic and clinical factor models. Mean decrease accuracy, mean decrease Gini, and a chi-square test identified T stage, age, and disease site as the most important clinical factors in prognosis prediction; (4) Conclusions: our radiomic-clinical combined model revealed superior performance when compared to radiomic and clinical factor models alone. Further prospective research with a larger sample size is warranted to implement the model for clinical use. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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