Genetic associations with consumption of palatable foods in the absence of hunger in response to food cues in children.

Autor: Yeum D; Department of Epidemiology, Geisel School of Medicine at Dartmouth College, Lebanon, New Hampshire, USA., Renier TJ; Department of Epidemiology, Geisel School of Medicine at Dartmouth College, Lebanon, New Hampshire, USA., Masterson TD; Department of Nutritional Sciences, College of Health and Human Development, The Pennsylvania State University, University Park, Pennsylvania, USA., Carlson DD; Department of Epidemiology, Geisel School of Medicine at Dartmouth College, Lebanon, New Hampshire, USA., Ballarino GA; Department of Epidemiology, Geisel School of Medicine at Dartmouth College, Lebanon, New Hampshire, USA., Lansigan RK; Department of Pediatrics, Geisel School of Medicine at Dartmouth College, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, USA., Loos RJF; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty for Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Emond JA; Department of Pediatrics, Geisel School of Medicine at Dartmouth College, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, USA.; Department of Biomedical Data Science, Geisel School of Medicine at Dartmouth College, Lebanon, New Hampshire, USA., Gilbert-Diamond D; Department of Epidemiology, Geisel School of Medicine at Dartmouth College, Lebanon, New Hampshire, USA.; Department of Pediatrics, Geisel School of Medicine at Dartmouth College, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, USA.; Department of Medicine, Geisel School of Medicine at Dartmouth College, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, USA.
Jazyk: angličtina
Zdroj: Pediatric obesity [Pediatr Obes] 2024 Aug 28, pp. e13168. Date of Electronic Publication: 2024 Aug 28.
DOI: 10.1111/ijpo.13168
Abstrakt: Objective: The objective of this study is to evaluate obesity-related genetic factors in relation to excess consumption and assess if food cues modify associations.
Methods: Children (9-12 years) completed a randomized crossover experiment. During two visits, children ate a preload and then snacks ad libitum while watching television, embedded with food or non-food advertisements to assess eating in the absence of hunger (EAH). Primary exposures were obesity-associated genotypes, FTO rs9939609 and MC4R rs571312, and a paediatric-specific polygenic risk score (PRS). Outcomes included consumption of all snacks (total EAH) and gummy candy only (gummy candy EAH). Linear mixed-effects models tested whether genetic exposures related to EAH outcomes. We tested for effect modification by food cues using multiplicative interaction terms.
Results: Among 177 children, each FTO risk allele was associated with a 30% increase in gummy candy EAH (p = 0.025) in adjusted models. Food cue exposure exacerbated associations between the FTO variant with gummy candy EAH (p = 0.046). No statistically significant associations were found between MC4R and EAH.
Conclusion: The results suggest children with the FTO rs9939609 risk allele may be predisposed to excess consumption of candy and that this association may be exacerbated by food cues.
(© 2024 World Obesity Federation.)
Databáze: MEDLINE
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