Serum metabolomics combined with gut microbiota reveals the effects of Polygala tenuifolia polysaccharide on the metabolic and microbial profiles in SAMP8 mouse.

Autor: Li Z; School of Pharmaceutical Sciences, Shandong University of Traditional Chinese Medicine, Jinan 250355, China., Li Y; School of Pharmaceutical Sciences, Shandong University of Traditional Chinese Medicine, Jinan 250355, China., Zhang J; School of Pharmaceutical Sciences, Shandong University of Traditional Chinese Medicine, Jinan 250355, China., Liu Q; School of Pharmaceutical Sciences, Shandong University of Traditional Chinese Medicine, Jinan 250355, China., Zhu L; Sishui Siheyuan Culture and Tourism Development Company, Ltd, Sishui 273200, China., Mao B; School of Pharmaceutical Sciences, Shandong University of Traditional Chinese Medicine, Jinan 250355, China. Electronic address: Maobeibei89@163.com., Ma Y; School of Pharmaceutical Sciences, Shandong University of Traditional Chinese Medicine, Jinan 250355, China. Electronic address: mayan@sdutcm.edu.cn., Liu Y; School of Pharmaceutical Sciences, Shandong University of Traditional Chinese Medicine, Jinan 250355, China. Electronic address: yhliu@sdutcm.edu.cn.
Jazyk: angličtina
Zdroj: Journal of pharmaceutical and biomedical analysis [J Pharm Biomed Anal] 2024 Dec 15; Vol. 251, pp. 116442. Date of Electronic Publication: 2024 Aug 22.
DOI: 10.1016/j.jpba.2024.116442
Abstrakt: Polygala tenuifolia is a well-known traditional Chinese medicine. Polygala tenuifolia polysaccharide (PTP), as one of its main active ingredients, has excellent neuroprotective activity. PTP improved the disruption of the endogenous metabolites and gut microbiota caused by Alzheimer's disease (AD). Specifically, untargeted metabolomics results showed that 19 metabolites such as leukotriene B4, vanylglycol, and cer(d18:1/18:0) are significantly reduced, and 2 metabolites are elevated. It was significantly enriched in Sphingolipid metabolism, Glycerophospholipid metabolism, Tyrosine metabolism, and Arachidonic acid metabolism. Meanwhile, 16S rDNA analysis showed that PTP treatment significantly increased the relative abundance of bacteria such as Alistipes, Lachnospiraceae_NK4A136_group, and Lachnospiraceae_UCG-006. In addition, Spearman analysis showed that significant changes in gut microbiota were closely related to differential endogenous metabolites.
Competing Interests: Declaration of Competing Interest The authors confirm that there are no conflicts of interest.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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